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Table 1 Cell Permissiveness of Zika Virus (ZIKV)

From: Determination of the Cell Permissiveness Spectrum, Mode of RNA Replication, and RNA-Protein Interaction of Zika Virus

Host cell infected ZIKV (MR766) ZIKV (PRVABC59)
Protein RNA Protein RNA
Human fibroblast cells
 HFF (ATCC® SCRC-1041™)
 MRC-5 (ATCC® CCL-171™) ++++ ++++ ++++ ++++
 BJ (ATCC® CRL-2522™) +/− +/−
Human Epithelial cells
 ARPE-19 (ATCC® CRL-2302™) + + + +
 A549 (ATCC® CCL-185™) ++ ++ ++ ++
 HT1080 (ATCC® CCL-121™) +/− +/− +/− +/−
 Hep-2 (ATCC® CCL-23™)
 HEK 293T(ATCC® CRL-1573™) + + + +/−
Human Endothelial cells
 SLK (AIDSRP, cat# 9402)
Human blood cells
 CEM/CD4 T cell (AIDSRP, cat# 117) +/− +/− +/− +/−
 THP-1 (AIDSRP, cat# 9949)
 PBMC (ATCC® PCS-800-011™) ++ ++ ++ ++
Other Human cells
 U-251MG (SIGMA 09063001) ++++ ++++ ++++ ++++
 Neural Stem cell +++ +++ +++ +++
 SK-N-SH (ATCC® HTB-11™) ++++ ++++ ++++ ++++
Simian cells
 Vero (ATCC® CCL-81™) ++++ ++++ ++++ ++++
 COS7 (ATCC® CRL-1651™) ++++ ++++ ++++ ++++
Mouse cells
 MEF
 NIH3T3 (ATCC® CRL-1658™)
  1. The cells were infected with ZIKV at an MOI of 1 for 48 h, and fixed to perform immunostaining using anti-ZIKV antibody and RISH (RNA in situ hybridization) using the probe against ZIKV genome. Total cells (DAPI) and positive cells (ZIKV protein and/or RNA replication) were counted to calculate the positive rate (Positive rate = positive cell counted / total cells counted). HFF human foreskin fibroblast, MEF mouse embryo fibroblast. -: less than 3%; +/−: 3–5%; +: 5–10%; ++: 10–30%; +++: 30–70%; More than 70% positive rate defines ++++. AIDSRP AIDS Reagent Program