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Table 3 Odds ratios for exposures among pDILI Type 1 cases compared with controls

From: Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK

  Crude odds ratio (95% CI) Adjusted odds ratio (95% CI)a
Log baseline ALT (IU/L) 2.28 (0.96, 5.42) 1.96 (0.76, 5.04)
Log baseline ALP (IU/L) 6.67 (1.50, 29.7) 7.33 (1.46, 36.8)
Log baseline BILI (umol/L) 1.93 (0.56, 6.67) 2.20 (0.60, 8.01)
Weight (kg) 0.97 (0.95, 0.99) 0.96 (0.94, 0.99)
Rifampicin dose per kg 1.10 (0.93, 1.31) 1.12 (0.93, 1.35)
Isoniazid dose per kg 1.62 (1.22, 2.13) 1.77 (1.30, 2.40)
Pyrazinamide dose per kg 1.04 (1.00, 1.08) 1.04 (1.00, 1.09)
Moxifloxacin dose per kg 1.52 (0.83, 2.78) 1.53 (0.72, 3.27)
HIV 3.50 (0.91, 13.4) 4.40 (1.06, 18.3)
Alcohol Nil 1.00 (reference) 1.00 (reference)
  Any 6.00 (2.59, 13.9) 5.94 (2.34, 15.1)
  1. a Adjusted for age, sex and baseline ALT, ALP and bilirubin