|
Baseline ALT (IU/L)
| |
19 (14–29), n = 185
|
24 (17–32), n = 77
|
0.03
|
|
Baseline ALP (IU/L)
| |
86 (71–102), n = 187
|
98 (75–135), n = 77
|
0.03
|
|
Baseline bilirubin (umol/L)
|
8 (5–10), n = 185
|
8 (6–12), n = 77
|
0.28
|
|
Weight (kg)
| |
61.2 (54.5–69.6), n = 178
|
53.9 (48.0–65.0), n = 74
|
0.001
|
|
Rifampicin dose per kg
|
(if given)
|
9.68 (8.62–10.7), n = 178
|
9.98 (9.00–11.1), n = 74
|
0.17
|
|
Isoniazid dose per kg
|
(if given)
|
4.85 (4.31–5.45), n = 178
|
5.57 (4.62–6.25), n = 74
|
<0.001
|
|
Pyrazinamide dose per kg
|
(if given)
|
24.4 (21.4–27.5), n = 178
|
25.8 (22.7–29.8), n = 74
|
0.05
|
|
Moxifloxacin dose per kg
|
(if given)
|
6.15 (5.71–7.04), n = 21
|
7.67 (5.71–8.00), n = 10
|
0.20
|
| | |
% (fraction)
|
% (fraction)
| |
|
HIV positive
| |
2.2 (4/185)
|
7.3 (5/69)
|
0.06
|
|
HCV positive
| |
1.7 (3/179)
|
1.4 (1/73)
|
1.00
|
|
HBV positive
| |
2.2 (4/180)
|
0.0 (0/74)
|
0.33
|
|
Alcohol consumptiona
|
Nil
|
93.3 (167/179)
|
71.4 (40/56)
|
<0.001
|
| |
Any
|
6.7 (12/179)
|
28.6 (16/56)
| |
|
Chronic Liver Disease
| |
2.2 (4/186)
|
3.9 (3/77)
|
0.42
|
