Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK

BMC Infectious Diseases

Table 1 Baseline characteristics of all cases of possible DILI (pDILI)

Characteristic		n (%)
pDILI		105
Sex	Female	49 (46.7)
	Male	56 (53.3)
Age (years)	18–24	17 (16.2)
	25–29	22 (21.0)
	30–34	10 (9.5)
	35–39	13 (12.4)
	40–49	14 (13.3)
	50–59	12 (11.4)
	60+	17 (16.2)
Ethnic origin	Indian	55 (52.4)
	Pakistani	8 (7.6)
	Nepalese	8 (7.6)
	Afghan	2 (1.9)
	Somali	4 (3.8)
	Romanian	2 (1.9)
	Black	6 (5.7)
	White	11 (10.5)
	Asian (Other)	7 (6.7)
	Other	2 (1.9)
Site of tuberculosis
Pulmonary		21 (20)
Extrapulmonary		61 (58.1)
Both		23 (21.9)
Total culture confirmed		62 (59)
Fully sensitive TB		56 (53.3)
Isoniazid monoresistant TB		3 (2.9)
Multi-drug resistant TB		3 (2.9)
HIV positive		8/96 (7.6)
HCV positive (detectable RNA)		3/98 (3.0)
HBV positive		0/101 (0)
Alcohol Excess^a		9/105 (8.6)
Chronic Liver Disease^b		7/105 (6.7)
No risk factor^c		78/105 (74.2)
Other risk factors		Median (IQR), n
Baseline ALT (IU/L) (normal range 10–50)		24 (17–32), n = 77
Baseline ALP (IU/L) (normal range 30–130)		98 (75–135), n = 77
Baseline BILI (umol/L) (normal range 0–21)		8 (6–12), n = 77
Weight (kg)		53.9 (48.0–65.0), n = 74
Rifampicin dose per kg	(if given)	9.98 (9.00–11.1), n = 74
Isoniazid dose per kg	(if given)	5.57 (4.62–6.25), n = 74
Pyrazinamide dose per kg	(if given)	25.8 (22.7–29.8), n = 74
Moxifloxacin dose per kg	(if given)	7.34 (6.15–8.15), n = 36

^aAlcohol excess is defined as >21 units per week for men or >14 units per week for women. ^bCauses of chronic liver disease are as follows: hepatitis C (3), alcoholic liver disease (2), autoimmune hepatitis (1) and 1 drug related, secondary to methotrexate. ^cAs defined by ATS/BTS

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