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Table 1 Baseline characteristics of all cases of possible DILI (pDILI)

From: Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK

Characteristic   n (%)
pDILI   105
Sex Female 49 (46.7)
  Male 56 (53.3)
Age (years) 18–24 17 (16.2)
  25–29 22 (21.0)
  30–34 10 (9.5)
  35–39 13 (12.4)
  40–49 14 (13.3)
  50–59 12 (11.4)
  60+ 17 (16.2)
Ethnic origin Indian 55 (52.4)
  Pakistani 8 (7.6)
  Nepalese 8 (7.6)
  Afghan 2 (1.9)
  Somali 4 (3.8)
  Romanian 2 (1.9)
  Black 6 (5.7)
  White 11 (10.5)
  Asian (Other) 7 (6.7)
  Other 2 (1.9)
Site of tuberculosis   
Pulmonary   21 (20)
Extrapulmonary   61 (58.1)
Both   23 (21.9)
Total culture confirmed   62 (59)
Fully sensitive TB   56 (53.3)
Isoniazid monoresistant TB   3 (2.9)
Multi-drug resistant TB   3 (2.9)
HIV positive   8/96 (7.6)
HCV positive (detectable RNA)   3/98 (3.0)
HBV positive   0/101 (0)
Alcohol Excessa   9/105 (8.6)
Chronic Liver Diseaseb   7/105 (6.7)
No risk factorc   78/105 (74.2)
Other risk factors   Median (IQR), n
Baseline ALT (IU/L) (normal range 10–50) 24 (17–32), n = 77
Baseline ALP (IU/L) (normal range 30–130) 98 (75–135), n = 77
Baseline BILI (umol/L) (normal range 0–21) 8 (6–12), n = 77
Weight (kg)   53.9 (48.0–65.0), n = 74
Rifampicin dose per kg (if given) 9.98 (9.00–11.1), n = 74
Isoniazid dose per kg (if given) 5.57 (4.62–6.25), n = 74
Pyrazinamide dose per kg (if given) 25.8 (22.7–29.8), n = 74
Moxifloxacin dose per kg (if given) 7.34 (6.15–8.15), n = 36
  1. aAlcohol excess is defined as >21 units per week for men or >14 units per week for women. bCauses of chronic liver disease are as follows: hepatitis C (3), alcoholic liver disease (2), autoimmune hepatitis (1) and 1 drug related, secondary to methotrexate. cAs defined by ATS/BTS