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Table 3 Case definition on the bases of the diagnostic test results

From: Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

Confirmed PCR positive and/or IgM positive plus PRNT positivea, and/or seroconversion or four fold increase in neutralizing antibody titers in two consecutive samples.
Probable IgM positive plus PRNT border lineb in acute samplesc.
Possible IgM negative and PRNT positive/border line, or IgM positive but PRNT negative in acute samples.
Not confirmed IgM positive and PRNT negative in late/convalescent samples, or PRNT positive without an increase in the titer in two consecutive samples.
  1. aPRNT80 ≥ 10: positive
  2. bPRNT50 ≥ 10: border line (b.l.)
  3. cThese cases were classified as possible if PRNT b.l. results were obtained toward different viruses