Fig. 7
From: Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo
PHA767491 attenuates HSV-1 viral titers in animal model. RIP3 knockout mice were pretreated with DMSO or PHA767491 via intraperitoneal injection and infected with HSV-1 of 2× 107 pfus per mouse by intraperitoneal injection for 2 days. The viral titers in livers (a) and spleens (b) were determined by plaque assay. c The viral titers in the livers from RIP3 knockout mice were measured by immunohistochemistry. Arrows indicated the expression of viral protein gB. The results shown here are representative of seven mice (n = 7 per group)