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Table 3 Progression to TB following LTBI testing with IGRAs and TST in children, immunocompromised and recently arrived immigrants

From: Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis

Study ID (First author, year) Total test results available Type of IGRA test and TST (thresholds) Number of people with positive results Number of people with negative results People with test positive results who progressed to TB (n) People with test negative results who progressed to TB (n)
Children
 Diel, 2011 [11] 104 QFT-GIT 21 83 6 0
TST (≥5 mm) 40 64 6 0
TST (≥10 mm) 40 64 4 2
 Mahomed, 2011 [13] 5244 QFT-GIT 2669 2575 39 13
TST (≥5 mm) 2894 2350 40 12
 Metin Timur, 2014 [14] 69 QFT-GIT 0 69 0 0
TST (≥15 mm) 69 0 0 0
 Noorbakhsh, 2011 [15] 59 QFT-G 18 41 10 0
58 TST (≥10 mm) 8 50 3 7
 Song, 2014 [16] 2966 QFT-GIT 317 2649 11 12
2982 TST (≥10 mm) 663 2319 13 10
TST (≥15 mm) 231 2751 13 10
Immunocompromised
 Elzi, 2011 [12] 43 T-SPOT.TB 25 18 25 18
44 TST (≥5 mm) 22 22 22 22
 Kim, 2011 [17] 265 T-SPOT.TB 89 176 4 0
288 TST (≥5 mm) 26 262 1 3
 Kim, 2015a [18] 282 QFT-GIT 7 275 0 1
282 TST (≥5 mm) 12 270 0 1
 Lee, 2009 [19] 30 QFT-G 12 18 1 0
T-SPOT.TB 15 17 0 2
TST (≥10 mm) 20 12 1 1
 Lee, 2014 [22] 159 QFT-GIT 26 133 3 2
169 TST (≥10 mm) 19 150 0 5
TST (≥15 mm) 12 157 0 5
 Lee, 2015b [23] 342 QFT-GIT 103 239 N/A 4
239 TST (≥10 mm) 60 179 2 2
 Milman, 2011 [20] 41 QFT-G 0 41 0 0
12 TST (≥10 mm) 0 12 0 0
 Moon, 2013 [21] 210 QFT-GIT 40 170 1 1
244 TST (≥5 mm) 39 205 0 2
 Sester, 2014 [24] 1238 QFT-GIT 159 1079 3 5
1217 T-SPOT.TB 193 1024 4 6
1282 TST (≥5 mm) 149 1133 4 7
 Sherkat, 2014 [25] 44 T-SPOT.TB 6 38 1 0
TST (≥10 mm) 8 36 1 0
Recent arrivals from countries with a high incidence of TB
 Harstad, 2010 [26] 815 QFT-GIT 238 577 8 1
  TST (≥6 mm) 415 395 8 1
813 TST (≥15 mm) 121 692 3 6
 Kik, 2010 [27] 327 QFT-GIT 178 149 5 3
299 T-SPOT.TB 181 118 6 2
339 TST (≥10 mm) 288 51 9 0
322 TST (≥15 mm) 184 138 7 1
  1. N/A not applicable, QFT-G quantiferon gold, QFT-GIT quantiferon gold-in-tube, TB tuberculosis, TST tuberculin skin test, n number
  2. aOne unique study but three sub-groups received testing (TST alone, QFT-GIT alone and TST and QFT-GIT simultaneously)
  3. bPeople with a positive result on QFT-GIT received TB preventative treatment