Skip to main content

Table 3 Progression to TB following LTBI testing with IGRAs and TST in children, immunocompromised and recently arrived immigrants

From: Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis

Study ID (First author, year)

Total test results available

Type of IGRA test and TST (thresholds)

Number of people with positive results

Number of people with negative results

People with test positive results who progressed to TB (n)

People with test negative results who progressed to TB (n)

Children

 Diel, 2011 [11]

104

QFT-GIT

21

83

6

0

TST (≥5 mm)

40

64

6

0

TST (≥10 mm)

40

64

4

2

 Mahomed, 2011 [13]

5244

QFT-GIT

2669

2575

39

13

TST (≥5 mm)

2894

2350

40

12

 Metin Timur, 2014 [14]

69

QFT-GIT

0

69

0

0

TST (≥15 mm)

69

0

0

0

 Noorbakhsh, 2011 [15]

59

QFT-G

18

41

10

0

58

TST (≥10 mm)

8

50

3

7

 Song, 2014 [16]

2966

QFT-GIT

317

2649

11

12

2982

TST (≥10 mm)

663

2319

13

10

TST (≥15 mm)

231

2751

13

10

Immunocompromised

 Elzi, 2011 [12]

43

T-SPOT.TB

25

18

25

18

44

TST (≥5 mm)

22

22

22

22

 Kim, 2011 [17]

265

T-SPOT.TB

89

176

4

0

288

TST (≥5 mm)

26

262

1

3

 Kim, 2015a [18]

282

QFT-GIT

7

275

0

1

282

TST (≥5 mm)

12

270

0

1

 Lee, 2009 [19]

30

QFT-G

12

18

1

0

T-SPOT.TB

15

17

0

2

TST (≥10 mm)

20

12

1

1

 Lee, 2014 [22]

159

QFT-GIT

26

133

3

2

169

TST (≥10 mm)

19

150

0

5

TST (≥15 mm)

12

157

0

5

 Lee, 2015b [23]

342

QFT-GIT

103

239

N/A

4

239

TST (≥10 mm)

60

179

2

2

 Milman, 2011 [20]

41

QFT-G

0

41

0

0

12

TST (≥10 mm)

0

12

0

0

 Moon, 2013 [21]

210

QFT-GIT

40

170

1

1

244

TST (≥5 mm)

39

205

0

2

 Sester, 2014 [24]

1238

QFT-GIT

159

1079

3

5

1217

T-SPOT.TB

193

1024

4

6

1282

TST (≥5 mm)

149

1133

4

7

 Sherkat, 2014 [25]

44

T-SPOT.TB

6

38

1

0

TST (≥10 mm)

8

36

1

0

Recent arrivals from countries with a high incidence of TB

 Harstad, 2010 [26]

815

QFT-GIT

238

577

8

1

 

TST (≥6 mm)

415

395

8

1

813

TST (≥15 mm)

121

692

3

6

 Kik, 2010 [27]

327

QFT-GIT

178

149

5

3

299

T-SPOT.TB

181

118

6

2

339

TST (≥10 mm)

288

51

9

0

322

TST (≥15 mm)

184

138

7

1

  1. N/A not applicable, QFT-G quantiferon gold, QFT-GIT quantiferon gold-in-tube, TB tuberculosis, TST tuberculin skin test, n number
  2. aOne unique study but three sub-groups received testing (TST alone, QFT-GIT alone and TST and QFT-GIT simultaneously)
  3. bPeople with a positive result on QFT-GIT received TB preventative treatment