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Table 2 Risk of bias in studies of active TB incidence comparing IGRA with TST in children, immunocompromised people and recently arrived people from countries with a high incidence of TB

From: Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis

First author, Year Study Participation Study Attrition Prognostic Factor Measurement Outcome/Construct Measurement Study Confounding Statistical Analysis and Reporting Total ROB
Children
 Diel, 2011 [11] Low Low Moderate Moderate Low Low Moderate ROB
 Mahomed, 2011 [13] Moderate Moderate Moderate Moderate High Low Moderate ROB
 Metin Timur 2014 [14] High High Moderate Moderate High High High ROB
 Noorbakhsh 2011 [15] High High High Moderate High High High ROB
 Song, 2014 [16] Low Moderate Low High Moderate Low Moderate ROB
Immunocompromised
 Elzi, 2011 [12] High Low Low Moderate High Low High ROB
 Kim, 2011 [17] Low Low Low Low Moderate Low Low ROB
 Kim, 2015 [18] Low Low Low Low High Low Low ROB
 Lee, 2009 [19] High Low Low Moderate High Low High ROB
 Lee, 2014 [22] High Moderate Moderate Moderate Low Low Moderate ROB
 Lee, 2015 [23] Low Low Moderate Low High Low Low ROB
 Milman, 2014 [20] Low Low Moderate Low Low Low Low ROB
 Moon, 2013 [21] Moderate Low Moderate Moderate Moderate Low Moderate ROB
 Sester, 2014 [24] Low Low Moderate Low High Low Moderate ROB
 Sherkat, 2014 [25] High High Moderate High High Moderate High ROB
Recent arrivals from countries with a high incidence of TB
 Harstad, 2010 [26] High Low High Moderate High High High ROB
 Kik, 2010 [27] Low Low Low Low Low Low Low ROB
  1. IGRA interferon gamma release assay, ROB risk of bias, TST tuberculin skin test
  2. Risk of bias item responses (per domain, overall): high, moderate or low