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Table 3 Key Variables and Sources of Information for Hospitalized and Non-Ill Infants

From: Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods

 

Hospitalized Infants

Non-Ill Infants

Enrollment

3–5 Week Follow-Up

Hospital Records

Enrollment

Specimens

 Combined nasal and oropharyngeal swabs

√

  

√

 Blood (Sera)

√

√

  

 Endotracheal aspirate (for intubated infants)

√

   

Infant illness

 Date of illness onset and resolution

√

√

  

 Maternal-reported symptoms

√

√

  

 Ambulatory and self-care for illness

√

√

  

 Clinical signs at admission and per day

  

√

 

 Clinical diagnoses

  

√

 

 Clinical interventions

  

√

 

 Clinical laboratory results

  

√

 

 Clinical radiographic information

  

√

 

 Readmission to hospital

 

√

√

 

 Other hospitalizations post-discharge

 

√

√

 

Infant characteristics

 Demographic (sex, birth date, race, ethnicity) information

√

  

√

 Current weight

√

√

√

√

 Current length

√

√

√

√

 Perceived overall health and functioning

√

√

 

√

 Influenza vaccination status (from vaccination cards when available)

√

√

√

√

 Delivery characteristics (including gestational age, birth weight, complications and abnormalities)

√

 

√

√

 Diagnoses and history of care for chronic conditions

√

 

√

√

 Diagnoses and history of care for prior acute illnesses

√

 

√

√

 Results of previous laboratory tests

  

√

 

 Other immunization status

√

√

√

√

 Daycare attendance

√

  

√

Household characteristics

 Age of each household member

√

  

√

 Education and occupation of parents (or guardians)

√

  

√

 House size and number of rooms

√

  

√

 Subjective social status

√

  

√

 Household wealth index

√

  

√

 Household smoking

√

  

√

Maternal characteristics

 Subjective health status

√

√

 

√

 Medical conditions

√

  

√

 Pregnancy history and complications during study infant’s gestation

√

  

√

 History of and current breastfeeding

√

  

√

 Influenza vaccination status (from vaccination cards when available)

√

√

√

√

 Knowledge of and worry about influenza illness

 

√

 

√

 Knowledge of and attitudes toward influenza vaccine for infants aged ≥6 months

 

√

 

√