Table 5 Carbapenem-resistant K. pneumoniae bacteremias
N° | % | |
|---|---|---|
N° of cases | 14 | |
Mean age, years (range) | 51.5 (28–68) | |
Male/female | 5/9 | |
Acute leukemia | 13 | 93 |
Acute myeloid leukemia | 12 | 86 |
Other haematologic malignancy | 1 | 7 |
Intensive Induction /reinduction chemotherapy | 6 | 54 |
Intensive consolidation chemotherapy | 4 | 29 |
Days of hospitalization before bacteremia, mean, median (range), | 22.8, 17 (1–90) | |
No CRKP rectal carriers (n° of patients) | 3 | 21 |
CRKP rectal carriers (n° of patients) | 11 | 79 |
CRKP carrier from ≤ 2 days (n° of patients) | 5 | 36 |
Days spent CRKP colonized before bacteremia, mean, median, (range) | 38.5, 6, (1–180) | |
Multiple-sites CRKP colonization | 6 | 54 |
CRKP colonization acquired in the current hospitalization | 8 | 57 |
CRKP colonization acquired during a previous hospitalization | 3 | 21 |
Documented source of bacteremia | 7 | 50 |
labia and vaginal cellulitis | 3 | 21 |
hemorroidal cellulitis | 1 | 7 |
typhlitis | 2 | 14 |
lung | 1 | 7 |
Bacteremia of unknown origin (CRKP carriers) | 7 (4) | 50 |
Previous antibiotic treatment | 13 | 93 |
Piperacillin-tazobactam monotherapy | 11 | 79 |
Tigecyclin containing combination | 8 | 57 |
Carbapenem containing combination | 3 | 21 |
N° of patients with <1000 neutrophils/mmc at the onset of bacteremia | 12 | 86 |
N° of patients with < 100 neutrophils/mmc at the onset of bacteremia | 11 | 79 |
Shock | 8 | 57 |
Persistent bacteremia (≥3 days) | 9 | 64 |
- days of bacteremia, mean (range) | 4.6 (3–10) | |
Breakthrough bacteremia | 10 | 71 |
- days of antibiotic treatment before CRKP bacteremia onset: mean, median (range) | 3.6, 2 (1–10) | |
Overall (initial or subsequently modified) adequatea antibiotic treatment | 9 | 64 |
Initial adequate antibiotic treatment | 6b | 43 |
One “in vitro” active antibiotic | 5c | 36 |
More than 1 in vitro active antibiotics | 1d | 7 |
Response to adequate initial treatment | 2 | 14 |
Initial inadequate antibiotic treatment | 8e | 57 |
Modification of inadequate initial treatment (within 48 h) | 7 (6) | 50 |
Modification with adequate antibiotics | 3 | 21 |
Response to antibiotic treatment modification | 0 | |
Deaths | 10 | 71 |
Mean days for death (range) | 4.6 (2–12) | - |
Early death (within 72–96 h) | 5 | 36 |
Shock | 7 | 50 |
Breakthrough bacteremia | 8 | 57 |