Table 2 Characteristics of the 22 patients harbouring carbapenem-resistant K. pneumoniae
N° | % | |
|---|---|---|
PATIENTS | 22 | |
Male gender | 13 | 59 |
Age (years), mean (range) | 53.7 (28–76) | |
N° of patients who developed CRKP bacteremia | 14 | 64 |
- Previously identified as CRKP rectal carriers | 11 | |
N° of patients who remained CRKP rectal carriers | 8 | 36 |
UNDERLYING HAEMATOLOGIC MALIGNANCY | ||
Acute leukemia | 16 | 73 |
- Acute myeloid leukemia | 12 | 55 |
Other haematologic malignancy | 6 | 27 |
CHEMOTHERAPEUTIC TREATMENT | 20 | 91 |
Intensive remission induction/reinduction | 8 | 40 |
Intensive remission consolidation | 4 | 20 |
Other chemotherapy | 8 | 40 |
CHARACTERISTICS OF PATIENTS AT CRKP ACQUISITION (n° of patients) | ||
Rectum as first site of CRKP isolation | 19 | 86 |
Blood as first site of CRKP isolation | 3 | 14 |
Ongoing fluoroquinolones oral prophylaxis | 11 | 50 |
Ongoing systemic antibacterial treatment (carbapenem) | 9 (1) | 41 |
Carbapenems within the last 4 weeks | 5 | 23 |
<1000 neutrophils/mm3 | 12 | 55 |
<100 neutrophils /mm3 | 10 | 45 |
days with < 1000 neutrophils/mm3 before CRKP acquisition: mean, median (range), | 19.2,13 (2–53) | |
days with < 100 neutrophils /mm3 before CRKP acquisition: mean, median (range) | 10.2, 4.5, (1-53) | |
N° of patients negative at CRKP rectal screening performed at entry: | 19 | 86 |
First hospitalization (n° of patients) | 14 | 64 |
Transferred from other Departments | 2 | |
Prior hospitalization (n° of patients) | 5 | 23 |
During the period preceding CRKP acquisition: | ||
Mean, median (range) days of previous hospitalization | 28, 17 (7–60) | |
n°of patients hospitalized together with other CRKP-positive patients | 17/19 | |
n°of patients hospitalized together with 4 or more CRKP carriers | 11/19 | 86 |
n°of patients hospitalized together with 9 or more CRKP carriers | 6/19 | 64 |
n°of patients hospitalized when clinical emergencies occurred in other CRKP-positive patients a | 14/19 | |
CRKP bacteremia occurrence | 14/19 | |
death for any cause in at least 1 CRKP-positive patients | 10/19 | |
n° of patients temporary transferred to other Departments for invasive procedures | 4/19 | |
N° of patients positive at CRKP rectal screening performed at entry | 3 | 14 |
Previous hospitalization | 3 | |
Transferred from other Departments (n° of patients) | 2 | |
In the same Unit | 1 |