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Table 3 Genotype, allele frequency and MAF of TNFα, IL-10 and TLR4 gene polymorphisms in individuals with chronic and asymptomatic cutaneous leishmaniasis

From: Screening of TNFα, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study

SNPs   Frequency; N (%) P value OR (95% CI)
   Asymptomatic CCL   
TNFα-308      
 Genotype AA 1 (4) 0 (0) 0.45 b 0 (0–0)
GG 20 (71) 29 (85) 0.06 a 0.39 (0.14–1.05)
GA 7 (25) 5 (15) 0.30 a 1.93 (0.54–0.94)
 Allele A 9 (16) 5 (7) 0.13 a 2.41 (0.76–7.67)
G 47 (87) 63 (93) 0.13 a 0.41 (0.13–1.32)
 MAF   0.161 0.074 0.126 a  
IL-10-819      
 Genotype CC 6 (27) 11 (34) 0.21 a 0.49 (0.16–1.51)
TT 9 (41) 16 (50) 0.51 a 0.69 (0.23–2.07)
CT 7 (32) 5 (16) 0.16 a 2.52 (0.68–9.33)
 Allele C 19 (43) 27 (42) 0.92 a 1.04 (0.48–2.26)
T 25 (57) 37 (58) 0.92 a 0.96 (0.44–2.09)
 MAF   0.568 0.578 0.918 a  
TLR4 Asp299Gly      
 Genotype AA 28 (85) 28 (85) 0.45 b 1.25 (0.38–4.22)
GG 0 (0) 0 (0)
AG 5 (15) 5 (15) 0.63 b 1.00 (0.20–4.88)
 Allele A 61 (92) 61 (92) 0.63 b 1.00 (0.22–4.58)
G 5 (8) 5 (8) 0.63 b 1.00 (0.22–4.58)
 MAF   0.076 0.076 1.000 a  
TLR4 Thr399Ile      
 Genotype CC 34 (100) 34 (100)
TT 0 (0) 0 (0)
CT 0 (0) 0 (0)
 Allele C 68 (100) 68 (100)
T
 MAF   0.000 0.000  
  1. a Chi square test
  2. b Fisher exact test (one-tail)