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Table 3 Genotype, allele frequency and MAF of TNFα, IL-10 and TLR4 gene polymorphisms in individuals with chronic and asymptomatic cutaneous leishmaniasis

From: Screening of TNFα, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study

SNPs

 

Frequency; N (%)

P value

OR (95% CI)

  

Asymptomatic

CCL

  

TNFα-308

     

 Genotype

AA

1 (4)

0 (0)

0.45 b

0 (0–0)

GG

20 (71)

29 (85)

0.06 a

0.39 (0.14–1.05)

GA

7 (25)

5 (15)

0.30 a

1.93 (0.54–0.94)

 Allele

A

9 (16)

5 (7)

0.13 a

2.41 (0.76–7.67)

G

47 (87)

63 (93)

0.13 a

0.41 (0.13–1.32)

 MAF

 

0.161

0.074

0.126 a

 

IL-10-819

     

 Genotype

CC

6 (27)

11 (34)

0.21 a

0.49 (0.16–1.51)

TT

9 (41)

16 (50)

0.51 a

0.69 (0.23–2.07)

CT

7 (32)

5 (16)

0.16 a

2.52 (0.68–9.33)

 Allele

C

19 (43)

27 (42)

0.92 a

1.04 (0.48–2.26)

T

25 (57)

37 (58)

0.92 a

0.96 (0.44–2.09)

 MAF

 

0.568

0.578

0.918 a

 

TLR4 Asp299Gly

     

 Genotype

AA

28 (85)

28 (85)

0.45 b

1.25 (0.38–4.22)

GG

0 (0)

0 (0)

AG

5 (15)

5 (15)

0.63 b

1.00 (0.20–4.88)

 Allele

A

61 (92)

61 (92)

0.63 b

1.00 (0.22–4.58)

G

5 (8)

5 (8)

0.63 b

1.00 (0.22–4.58)

 MAF

 

0.076

0.076

1.000 a

 

TLR4 Thr399Ile

     

 Genotype

CC

34 (100)

34 (100)

TT

0 (0)

0 (0)

CT

0 (0)

0 (0)

 Allele

C

68 (100)

68 (100)

T

 MAF

 

0.000

0.000

 
  1. a Chi square test
  2. b Fisher exact test (one-tail)