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Table 3 Multivariate time independent and dependent Cox regression models

From: Systemic inflammation-based scores and mortality for all causes in HIV-infected patients: a MASTER cohort study

   Time independent models   Time dependent models   
   HR (95% CI)a P value HR (95% CI)a P value HR (95% CI)a P value HR (95% CI)a P value
Gender Male vs Famale 1.06 (0.81–1.37) NS 1.25 (0.92–1.69) NS 1.01 (0.77–1.33) NS 1.09 (0.80–1.47) NS
Age at enrolment (years) <25 Ref NS Ref NS Ref   Ref  
25–34 2.02 (0.88–4.65) 0.098 3.31 (1.04–10.58) 0.043 1.59 (0.69–3.68) NS 1.61 (0.64–4.04) NS
35–44 2.56 (1.12–5.84) 0.025 4.34 (1.37–13.73) 0.013 1.94 (0.85–4.43) NS 2.07 (0.84–5.13) NS
45–54 5.05 (2.20–11.59) <0.001 8.56 (2.69–27.25) <0.001 4.35 (1.89–9.99) 0.001 4.65 (1.87–11.58) 0.001
≥55 6.8 (2.91–16.05) <0.001 12.08 (3.71–39.27) <0.001 4.93 (2.09–11.66) <0.001 5.78 (2.25–14.84) <0.001
IDU Yes vs No 2.6 (2.09–3.25) <0.001 2.46 (1.91–3.16) <0.001 2.25 (1.77–2.86) <0.001 2.3 (1.77–2.99) <0.001
AIDS-event Yes vs No      1.50 (1.09–2.06) 0.012 1.43 (1.00–2.06) 0.052
CD4 cell count, cell/mm3 0–49 6.32 (4.30–9.30) <0.001 4.9 (3.23–7.45) <0.001 27.46 (17.67–42.65) <0.001 16.65 (10.26–27.02) <0.001
50–99 3.62 (2.41–5.43) <0.001 2.47 (1.54–3.96) <0.001 10.53 (6.64–16.71) <0.001 6.19 (3.68–10.41) <0.001
100–199 2.55 (1.76–3.69) <0.001 2.26 (1.50–3.40) <0.001 5.42 (3.61–8.13) <0.001 4.31 (2.79–6.66) <0.001
200–349 1.91 (1.35–2.72) <0.001 1.8 (1.22–2.65) 0.003 3.22 (2.22–4.67) <0.001 2.75 (1.84–4.11) <0.001
350–499 1.35 (0.92–1.98) NS 1.43 (0.95–2.17) 0.090 1.57 (1.05–2.36) 0.030 1.57 (1.02–2.41) 0.040
≥500 Ref     Ref   Ref  
PLR <100 1.57 (1.23–1.99) <0.001    1.47 (1.14–1.90) 0.003   
100–200 Ref     Ref    
≥200 1.34 (1.02–1.75) 0.034    1.42 (1.06–1.89) 0.017   
NLR <2    Ref     Ref  
2–4    1.17 (0.90–1.53) NS    1.47 (1.12–1.92) 0.005
≥4    1.82 (1.28–2.60) 0.001    2.78 (1.97–3.91) <0.001
Antiretroviral therapy No therapy vs cART      1.28 (1.01–1.63) 0.043 1.47 (1.13–1.91) 0.004
  1. Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, IDU intravenous drug use, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio
  2. aAdjusted for all the variables in the model. Time independent Cox regression models included variables at enrolment. Time-dependent Cox regression models included gender, age at enrolment, intravenous drug use as fixed covariates, and PLR, NLR, CD4 cell count, AIDS events, antiretroviral therapy as time-dependent covariates, considering at enrolment and every year. The observational period were divided into intervals of 1-year duration