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Table 3 Multivariate time independent and dependent Cox regression models

From: Systemic inflammation-based scores and mortality for all causes in HIV-infected patients: a MASTER cohort study

  

Time independent models

 

Time dependent models

  
  

HR (95% CI)a

P value

HR (95% CI)a

P value

HR (95% CI)a

P value

HR (95% CI)a

P value

Gender

Male vs Famale

1.06 (0.81–1.37)

NS

1.25 (0.92–1.69)

NS

1.01 (0.77–1.33)

NS

1.09 (0.80–1.47)

NS

Age at enrolment (years)

<25

Ref

NS

Ref

NS

Ref

 

Ref

 

25–34

2.02 (0.88–4.65)

0.098

3.31 (1.04–10.58)

0.043

1.59 (0.69–3.68)

NS

1.61 (0.64–4.04)

NS

35–44

2.56 (1.12–5.84)

0.025

4.34 (1.37–13.73)

0.013

1.94 (0.85–4.43)

NS

2.07 (0.84–5.13)

NS

45–54

5.05 (2.20–11.59)

<0.001

8.56 (2.69–27.25)

<0.001

4.35 (1.89–9.99)

0.001

4.65 (1.87–11.58)

0.001

≥55

6.8 (2.91–16.05)

<0.001

12.08 (3.71–39.27)

<0.001

4.93 (2.09–11.66)

<0.001

5.78 (2.25–14.84)

<0.001

IDU

Yes vs No

2.6 (2.09–3.25)

<0.001

2.46 (1.91–3.16)

<0.001

2.25 (1.77–2.86)

<0.001

2.3 (1.77–2.99)

<0.001

AIDS-event

Yes vs No

    

1.50 (1.09–2.06)

0.012

1.43 (1.00–2.06)

0.052

CD4 cell count, cell/mm3

0–49

6.32 (4.30–9.30)

<0.001

4.9 (3.23–7.45)

<0.001

27.46 (17.67–42.65)

<0.001

16.65 (10.26–27.02)

<0.001

50–99

3.62 (2.41–5.43)

<0.001

2.47 (1.54–3.96)

<0.001

10.53 (6.64–16.71)

<0.001

6.19 (3.68–10.41)

<0.001

100–199

2.55 (1.76–3.69)

<0.001

2.26 (1.50–3.40)

<0.001

5.42 (3.61–8.13)

<0.001

4.31 (2.79–6.66)

<0.001

200–349

1.91 (1.35–2.72)

<0.001

1.8 (1.22–2.65)

0.003

3.22 (2.22–4.67)

<0.001

2.75 (1.84–4.11)

<0.001

350–499

1.35 (0.92–1.98)

NS

1.43 (0.95–2.17)

0.090

1.57 (1.05–2.36)

0.030

1.57 (1.02–2.41)

0.040

≥500

Ref

   

Ref

 

Ref

 

PLR

<100

1.57 (1.23–1.99)

<0.001

  

1.47 (1.14–1.90)

0.003

  

100–200

Ref

   

Ref

   

≥200

1.34 (1.02–1.75)

0.034

  

1.42 (1.06–1.89)

0.017

  

NLR

<2

  

Ref

   

Ref

 

2–4

  

1.17 (0.90–1.53)

NS

  

1.47 (1.12–1.92)

0.005

≥4

  

1.82 (1.28–2.60)

0.001

  

2.78 (1.97–3.91)

<0.001

Antiretroviral therapy

No therapy vs cART

    

1.28 (1.01–1.63)

0.043

1.47 (1.13–1.91)

0.004

  1. Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, IDU intravenous drug use, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio
  2. aAdjusted for all the variables in the model. Time independent Cox regression models included variables at enrolment. Time-dependent Cox regression models included gender, age at enrolment, intravenous drug use as fixed covariates, and PLR, NLR, CD4 cell count, AIDS events, antiretroviral therapy as time-dependent covariates, considering at enrolment and every year. The observational period were divided into intervals of 1-year duration