| | |
Time independent models
| |
Time dependent models
| | |
|---|
| | |
HR (95% CI)a
|
P value
|
HR (95% CI)a
|
P value
|
HR (95% CI)a
|
P value
|
HR (95% CI)a
|
P value
|
|---|
|
Gender
|
Male vs Famale
|
1.06 (0.81–1.37)
|
NS
|
1.25 (0.92–1.69)
|
NS
|
1.01 (0.77–1.33)
|
NS
|
1.09 (0.80–1.47)
|
NS
|
|
Age at enrolment (years)
|
<25
|
Ref
|
NS
|
Ref
|
NS
|
Ref
| |
Ref
| |
|
25–34
|
2.02 (0.88–4.65)
|
0.098
|
3.31 (1.04–10.58)
|
0.043
|
1.59 (0.69–3.68)
|
NS
|
1.61 (0.64–4.04)
|
NS
|
|
35–44
|
2.56 (1.12–5.84)
|
0.025
|
4.34 (1.37–13.73)
|
0.013
|
1.94 (0.85–4.43)
|
NS
|
2.07 (0.84–5.13)
|
NS
|
|
45–54
|
5.05 (2.20–11.59)
|
<0.001
|
8.56 (2.69–27.25)
|
<0.001
|
4.35 (1.89–9.99)
|
0.001
|
4.65 (1.87–11.58)
|
0.001
|
|
≥55
|
6.8 (2.91–16.05)
|
<0.001
|
12.08 (3.71–39.27)
|
<0.001
|
4.93 (2.09–11.66)
|
<0.001
|
5.78 (2.25–14.84)
|
<0.001
|
|
IDU
|
Yes vs No
|
2.6 (2.09–3.25)
|
<0.001
|
2.46 (1.91–3.16)
|
<0.001
|
2.25 (1.77–2.86)
|
<0.001
|
2.3 (1.77–2.99)
|
<0.001
|
|
AIDS-event
|
Yes vs No
| | | | |
1.50 (1.09–2.06)
|
0.012
|
1.43 (1.00–2.06)
|
0.052
|
|
CD4 cell count, cell/mm3
|
0–49
|
6.32 (4.30–9.30)
|
<0.001
|
4.9 (3.23–7.45)
|
<0.001
|
27.46 (17.67–42.65)
|
<0.001
|
16.65 (10.26–27.02)
|
<0.001
|
|
50–99
|
3.62 (2.41–5.43)
|
<0.001
|
2.47 (1.54–3.96)
|
<0.001
|
10.53 (6.64–16.71)
|
<0.001
|
6.19 (3.68–10.41)
|
<0.001
|
|
100–199
|
2.55 (1.76–3.69)
|
<0.001
|
2.26 (1.50–3.40)
|
<0.001
|
5.42 (3.61–8.13)
|
<0.001
|
4.31 (2.79–6.66)
|
<0.001
|
|
200–349
|
1.91 (1.35–2.72)
|
<0.001
|
1.8 (1.22–2.65)
|
0.003
|
3.22 (2.22–4.67)
|
<0.001
|
2.75 (1.84–4.11)
|
<0.001
|
|
350–499
|
1.35 (0.92–1.98)
|
NS
|
1.43 (0.95–2.17)
|
0.090
|
1.57 (1.05–2.36)
|
0.030
|
1.57 (1.02–2.41)
|
0.040
|
|
≥500
|
Ref
| | | |
Ref
| |
Ref
| |
|
PLR
|
<100
|
1.57 (1.23–1.99)
|
<0.001
| | |
1.47 (1.14–1.90)
|
0.003
| | |
|
100–200
|
Ref
| | | |
Ref
| | | |
|
≥200
|
1.34 (1.02–1.75)
|
0.034
| | |
1.42 (1.06–1.89)
|
0.017
| | |
|
NLR
|
<2
| | |
Ref
| | | |
Ref
| |
|
2–4
| | |
1.17 (0.90–1.53)
|
NS
| | |
1.47 (1.12–1.92)
|
0.005
|
|
≥4
| | |
1.82 (1.28–2.60)
|
0.001
| | |
2.78 (1.97–3.91)
|
<0.001
|
|
Antiretroviral therapy
|
No therapy vs cART
| | | | |
1.28 (1.01–1.63)
|
0.043
|
1.47 (1.13–1.91)
|
0.004
|
-
Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, IDU intravenous drug use, PLR platelet to lymphocyte ratio, NLR neutrophil to lymphocyte ratio
-
aAdjusted for all the variables in the model. Time independent Cox regression models included variables at enrolment. Time-dependent Cox regression models included gender, age at enrolment, intravenous drug use as fixed covariates, and PLR, NLR, CD4 cell count, AIDS events, antiretroviral therapy as time-dependent covariates, considering at enrolment and every year. The observational period were divided into intervals of 1-year duration
