Time independent models | Time dependent models | ||||||||
---|---|---|---|---|---|---|---|---|---|
HR (95% CI)a | P value | HR (95% CI)a | P value | HR (95% CI)a | P value | HR (95% CI)a | P value | ||
Gender | Male vs Famale | 1.06 (0.81–1.37) | NS | 1.25 (0.92–1.69) | NS | 1.01 (0.77–1.33) | NS | 1.09 (0.80–1.47) | NS |
Age at enrolment (years) | <25 | Ref | NS | Ref | NS | Ref | Ref | ||
25–34 | 2.02 (0.88–4.65) | 0.098 | 3.31 (1.04–10.58) | 0.043 | 1.59 (0.69–3.68) | NS | 1.61 (0.64–4.04) | NS | |
35–44 | 2.56 (1.12–5.84) | 0.025 | 4.34 (1.37–13.73) | 0.013 | 1.94 (0.85–4.43) | NS | 2.07 (0.84–5.13) | NS | |
45–54 | 5.05 (2.20–11.59) | <0.001 | 8.56 (2.69–27.25) | <0.001 | 4.35 (1.89–9.99) | 0.001 | 4.65 (1.87–11.58) | 0.001 | |
≥55 | 6.8 (2.91–16.05) | <0.001 | 12.08 (3.71–39.27) | <0.001 | 4.93 (2.09–11.66) | <0.001 | 5.78 (2.25–14.84) | <0.001 | |
IDU | Yes vs No | 2.6 (2.09–3.25) | <0.001 | 2.46 (1.91–3.16) | <0.001 | 2.25 (1.77–2.86) | <0.001 | 2.3 (1.77–2.99) | <0.001 |
AIDS-event | Yes vs No | 1.50 (1.09–2.06) | 0.012 | 1.43 (1.00–2.06) | 0.052 | ||||
CD4 cell count, cell/mm3 | 0–49 | 6.32 (4.30–9.30) | <0.001 | 4.9 (3.23–7.45) | <0.001 | 27.46 (17.67–42.65) | <0.001 | 16.65 (10.26–27.02) | <0.001 |
50–99 | 3.62 (2.41–5.43) | <0.001 | 2.47 (1.54–3.96) | <0.001 | 10.53 (6.64–16.71) | <0.001 | 6.19 (3.68–10.41) | <0.001 | |
100–199 | 2.55 (1.76–3.69) | <0.001 | 2.26 (1.50–3.40) | <0.001 | 5.42 (3.61–8.13) | <0.001 | 4.31 (2.79–6.66) | <0.001 | |
200–349 | 1.91 (1.35–2.72) | <0.001 | 1.8 (1.22–2.65) | 0.003 | 3.22 (2.22–4.67) | <0.001 | 2.75 (1.84–4.11) | <0.001 | |
350–499 | 1.35 (0.92–1.98) | NS | 1.43 (0.95–2.17) | 0.090 | 1.57 (1.05–2.36) | 0.030 | 1.57 (1.02–2.41) | 0.040 | |
≥500 | Ref | Ref | Ref | ||||||
PLR | <100 | 1.57 (1.23–1.99) | <0.001 | 1.47 (1.14–1.90) | 0.003 | ||||
100–200 | Ref | Ref | |||||||
≥200 | 1.34 (1.02–1.75) | 0.034 | 1.42 (1.06–1.89) | 0.017 | |||||
NLR | <2 | Ref | Ref | ||||||
2–4 | 1.17 (0.90–1.53) | NS | 1.47 (1.12–1.92) | 0.005 | |||||
≥4 | 1.82 (1.28–2.60) | 0.001 | 2.78 (1.97–3.91) | <0.001 | |||||
Antiretroviral therapy | No therapy vs cART | 1.28 (1.01–1.63) | 0.043 | 1.47 (1.13–1.91) | 0.004 |