The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data

Table 2 Cox regression analysis of predictors of virological failure

Factor	Univariable HR	p-value	Multivariable HR (95% CI)	p-value
Monitoring randomisation
LCM	1.00	-	1.00	-
CDM	1.07	0.45	1.11 (0.93 - 1.35)	0.25
Gender
Male	1.00	-	1.00	-
Female	0.80	0.02	0.79 (0.65 - 0.95)	0.01
Initial ART
TDF	1.00	<0.0001	1.00	<0.0001
NVP	0.49	-	0.48 (0.38 - 0.62)	-
ABC	1.18	-	1.27 (1.02 - 1.59)	-
TB in 12 months prior to enrolment	1.13	0.26	1.07 (0.86 - 1.33)	0.52
Age (per 10 years older)	0.73	<0.0001	0.73 (0.64 - 0.84)	<0.0001
Baseline CD4 (per 100 cells/mm³ higher)	0.60	<0.0001	0.64 (0.54 - 0.75)	<0.0001
Baseline viral load (log₁₀ copies/mL)	1.02	0.84	1.01 (0.84 - 1.22)	0.89
Adherence in previous 48 weeks^a (per 10% higher)	0.89	<0.0001	0.89 (0.84 - 0.94)	<0.0001

ISSN: 1471-2334