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Table 5 Univariable and multivariable analyses of risk factors for mortalitya

From: High mortality among tuberculosis patients on treatment in Nigeria: a retrospective cohort study

Variable

Crude HR (95% CI)

P value

Adjusted HR (95% CI)

p value

Age group (years)

 15–24

1

 

1

 

 25–34

1 · 62 (1 · 01–2 · 58)

 

1 · 18 (0 · 73–1 · 89)

 

 35–44

1 · 57 (0 · 97–2 · 53)

 

1 · 07 (0 · 65–1 · 77)

 

 45–54

3 · 79 (2 · 37–6 · 07)

 

2 · 37 (1 · 44–3 · 92)

 

 55–64

1 · 85 (0 · 96–3 · 57)

 

1 · 43 (0 · 73–2 · 80)

 

  > 65

3 · 60 (2 · 03–6 · 38)

<0 · 001

1 · 64 (0 · 90–2 · 99)

0.001

Gender

 Female

1

0 · 06

1

 

 Male

1 · 28 (0 · 99–1 · 67)

 

0 · 94 (0 · 71–1 · 25)

0 · 68

Residence

 Within Kano

1

 

1

 

 Outside Kano

6. · 74 (5 · 13–8 · 86)

<0 · 001

3 · 18 (2 · 28–4 · 45)

<0 · 001

Referral facility

 DOTS-linked facility

1

 

1

 

 Non DOTS-linked facility

5 · 85 (4 · 07–8 · 42)

<0 · 001

3 · 02 (2 · 01–4 · 53)

<0 · 001

TB diagnosis

 Bacteriological

1

 

1

 

 Clinical

10 · 72 (6 · 12–18 · 76)

<0 · 001

4 · 96 (2 · 69–9 · 17)

<0 · 001

TB site

 Pulmonary

1

 

1

 

 Extra-pulmonary

1 · 46 (1 · 00–2 · 14)

 

1 · 08 (0 · 72–1 · 63)

 

 Both

4 · 86 (3 · 68–6 · 42)

<0 · 001

1 · 45 (1 · 03–2 · 02)

0 · 09

HIV/ART status

 HIV-

1

 

1

 

 HIV+ on ART

0 · 43 (0 · 21–0 · 92)

 

1 · 51 (0 · 60–3 · 78)

 

 HIV+ not on ART

1 · 42 (1 · 09–1 · 86)

 

1 · 39 (1 · 04–1 · 85)

 

 Unknown HIV status

0 · 54 (0 · 32–0 · 93)

<0 · 001

0 · 77 (0 · 44–1 · 33)

0 · 05

Previous TB treatment

 No

1

 

1

 

 Yes

6 · 43 (4 · 95–8 · 35)

<0 · 001

3 · 48 (2 · 54–4 · 77)

<0 · 001

Year of diagnosis

 2010–2011

1

 

1

 

 2012

1 · 17 (0 · 86–1 · 60)

 

1 · 10 (0 · 78–1 · 56)

 

 2013

0 · 48 (0 · 36–0 · 68)

 

0 · 47 (0 · 32–0 · 69)

 

 2014

0 · 45 (0 · 29–0 · 70)

<0 · 001

0 · 45 (0 · 27–0 · 74)

<0 · 001

  1. aAdjusted for all variables in the table