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Table 2 Univariate and multivariate analyses of baseline predictors of poor multidrug-resistant tuberculosis treatment outcomes

From: Risk factors for poor multidrug-resistant tuberculosis treatment outcomes in Kyiv Oblast, Ukraine

  Univariate Analysis (N = 348) p value Multivariate Analysis (N = 328) p value
OR (95% CI) OR (95% CI)
Age 1.01 (0.99–1.04) 0.35 1.02 (0.99–1.04) 0.24
Male 2.73 (1.51–4.92) 0.001 1.86 (0.96–3.64) 0.07
Previous TB treatmenta 2.03 (1.05–3.93) 0.04 2.29 (1.06–4.94) 0.03
Passive Case Findingb 1.08 (0.12–9.85) 0.94 NA  
HIV negativec Ref   Ref  
HIV positive with ART 0.94 (0.44–2.00) 0.87 1.43 (0.58–3.54) 0.44
HIV positive without ART 6.65 (0.88–50.07) 0.07 10.07 (1.20–84.45) 0.03
Smear Positived 2.70 (1.55–4.70) 0.001 2.54 (1.37–4.70) 0.003
Alcohol 1.21 (0.60–2.47) 0.60 0.96 (0.42–2.22) 0.93
IVDU 0.92 (0.19–4.42) 0.91 0.26 (0.04–1.87) 0.18
Unemployed 2.17 (1.26–3.74) 0.01 1.97 (1.03–3.78) 0.04
Rural Residencee 1.69 (0.95–3.00) 0.08 NA  
Previous Incarceration 1.39 (0.30–6.39) 0.67 NA  
Known TB contact 0.46 (0.04–5.10) 0.52 NA  
Baseline Gene Xpert Test 1.36 (0.72–2.56) 0.34 1.31 (0.63–2.73) 0.47
XDR-TB 3.60 (0.84–15.47) 0.09 9.19 (1.17–72.06) 0.03
  1. Complete case analysis used in logistic regression
  2. OR odds ratio, CI Confidence Interval, ART anti-retroviral therapy, IVDU intravenous drug use, XDR extensively drug-resistant
  3. aMissing observations, N = 15
  4. bMissing observations, N = 2
  5. cMissing observations, N = 4
  6. dMissing observations, N = 1
  7. eMissing observations, N = 61; excluded from multivariate analysis because > 10% of data missing