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Table 1 Patient characteristics and outcome

From: Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults

Pt

Gender

Clinical features

Laboratory markers at time of liver biopsy

Chest X-ray findings

Abdominal (and other) ultrasound findings

Duration of anti-TB therapy pre-liver biopsy (Days)

Duration of anti-TB therapy post-liver biopsy (Months)

Outcome at 1 year follow-up

  

H

J

S

CD4 cells/μl

TBil μmol/l

ALT u/l

ALP u/l

GGT u/l

ALB g/l

     

1

F

Y

N

N

43

15

49

2339

1268

17

Normal

ALN

7a

13

R

2

F

Y

Y

N

55

40

56

106

194

17

Normal

H, ALN

9

9

R

3

M

N

N

N

17

7

98

1035

275

23

Extensive paratracheal and hilar shadowing, active TB, nodular shadowing

Normal

140

5

D

4

F

Y

Y

Y

6

35

32

654

547

15

Consolidation with breakdown in RUZ, cavitation

Findings NR

50

7

R

5

M

N

N

Y

175

31

110

280

194

14

Large paratracheal lymph nodes

Findings NR

Post-biopsy

9

R

6

F

N

N

N

96

44

94

1110

994

16

Reticulonodular shadowing, paratracheal lymph nodes

Findings NR

6

NR

R

7

F

Y

N

N

56

3

35

1088

873

15

Extensive reticulonodular shadows, miliary pattern

Findings NR

21a

<1

D

8

M

Y

N

N

157

16

37

467

401

17

Left PE

H, ALN

175

9

MDR-TB

9

M

Y

N

Y

117b

14

26c

387

112

18

Diaphragm pushed up. Other findings NR

H, Sp

13

NR

R

10

F

Y

N

Y

34

14

42

323

451

21

Nodular infiltrates in right lower zone

H, Sp

5

9

R

11

F

Y

N

N

123b

42

116

415

326

17

Miliary pattern

Normal

0

NR

R

12

F

Y

N

N

15b

6

11

186

78

15

Findings NR

H, ALN

Post-biopsy

1

D

13

F

Y

Y

N

163

21

30c

448

278

17

LUZ consolidation, opacities in RUZ, RMZ and LMZ. Hilar lymph nodes

H, ALN, Sp, ascites, (PE, PCE)

39

8

D

14

F

Y

Y

N

20

21

95

2226

1257

26

Fibrosis of right upper lobe, nodular infiltrates in both lower zones

ALN

121a

9

R

15

F

Y

Y

N

42d

24

33

541

599

24

Small bilateral PE

H

219

>8

XDR-TB

16

F

Y

Y

N

17d

65

57

1050

443

21

Right upper lobe infiltrates

ALN, Sp

121a

9

R

17

F

Y

Y

N

49

26

28

321

86

11

Bilateral opacification, miliary TB

ALN, Sp

103a

6

D

18

F

Y

N

Y

45

6

41

463

1075

20

Reticular infiltrates in RUZ and LUZ

H, ALN

50

6

R

19

M

Y

N

Y

59

32

55

297

321

20

Mediastinal widening, no infiltrates

H, ALN, Sp (PE, PCE)

97

3

D

20

M

Y

N

N

37

13

163

326

460

28

Findings NR

Not done

81a

>8

R

  1. Pt Patient, TB Tuberculosis, H hepatomegaly, J Jaundice, S Splenomegaly, CD4 cluster of differentiation 4, TBil Total Bilirubin, ALT alanine transaminase, ALP alkaline phosphatase, GGT gamma-glutamyltransferase, ALB albumin, F Female, M Male, Y Yes, N No, ALN Abdominal lymph node/s, aanti-TB therapy interrupted pre-biopsy due to abnormal liver enzymes, R Resolved, D Died, RUZ Right upper zone, NR not reported, PE Pleural effusion, MDR-TB Multidrug-resistant tuberculosis, bon Antiretroviral therapy, cSerology positive for Hepatitis B Surface Antigen, Sp Splenic lesions, LUZ Left upper zone, RMZ Right mid zone, LMZ Left mid zone, PCE Pericardial effusion, dART stopped 1–2 months pre-biopsy, XDR-TB Extensively drug-resistant tuberculosis