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Table 8 ROC curve results for each of the demographic categories in the population of n = 1490

From: The dubious value of cerebrospinal fluid adenosine deaminase measurement for the diagnosis of tuberculous meningitis

 

TBM positive (n)

TBM

negative (n)

ROC curve

Sensitivity (%)

Specificity

(%)

AUC

p value

Cut-off (U/L)

Adult patients

90

1345

0.86

<0.01

2.0/2.2

86.7/85.6

77.8/79.0

Paediatric patients

2

53

0.58

<0.33

0.6

100.0

41.5

Male patients

47

695

0.86

<0.01

2.2 (2.0)

89.4 (89.4)

75.3 (74.1)

Female patients

45

703

0.86

<0.01

2.0

82.2

81.1

HIV positive patients

77

846

0.83

<0.01

2.2 (2.0)

84.4 (85.7)

74.1 (72.8)

HIV negative patients

7

274

0.88

<0.01

0.6

100.0

70.1

Patients with CD4 count ≤ 350 × 106/L

58

653

0.83

<0.01

2.0

86.2

74.4

Patients with CD4 count < 350 × 106/L

4

114

0.93

<0.01

2.7

100.0

86.0

  1. Cut-offs represented was based on the Youden index. In adult patients the Youden index performed similar for cut-off of 2.0 U/L and 2.2 U/L. In brackets performance at a cut-off of 2.0 U/L is indicated