Table 7 Target and actual sensitivities and specificities at different CSF ADA levels

Target Sensitivity

First cut-off closest the these targets

Actual Sensitivity

Corresponding Specificity

≥80%

2.3 U/L

81.5%

79.4%

≥85%

2.0 U/L

85.9%

77.7%

≥90%

0.8 U/L

91.3%

57.4%

≥95%

0.5 U/L

95.7%

43%

Target Specificity

First cut-off closest the these targets

Actual Specificity

Corresponding Sensitivity

≥80%

2.4 U/L

80%

78.3%

≥85%

3.3 U/L

85%

68.5%

≥90%

4.5 U/L

90%

55.4%

≥95%

7.3 U/L

95%

33.7%