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Table 2 Genes having the highest differential expression associated with immune response-related pathways

From: Transcriptome profiling of gene expression during immunisation trial against Fasciola hepatica: identification of genes and pathways involved in conferring immunoprotection in a murine model

Gene symbol

Description

p-value

Fold change

Associated pathway

S100A8

S100 calcium binding protein A8

1.62E-03

5.934

IL12 signalling and production in macrophages

Production of nitric oxide and reactive oxygen species

MMP9

Matrix metallopeptidase 9

3.07E-03

4.501

IL8 signalling

Leukocyte extravasation signalling

CXCR2

Chemokine (C-X-C motif) receptor 2

3.39E-04

3.401

IL8 signalling

IFITM1

Interferon induced transmembrane protein 1

2.13E-03

2.375

IFN signalling

CCR3

Chemokine (C-C motif) receptor 3 Gene

1.31E-03

1.655

CCR3 signalling in eosinophils

Chemokine signalling

ACTA2

Actin, alpha 2, smooth muscle, aorta

1.77E-03

1.640

Crosstalk between DC and NK cells

Leukocyte extravasation signalling

Integrin signalling

TAB1

Mitogen-activated protein kinase 7 interacting protein 1

2.82E-03

1.276

iNOS signalling

NF-kB signalling

IL10 signalling

Toll-like receptor signalling

CD40LG

CD40 ligand

1.41E-03

−1.740

T helper cell differentiation

CD40 signalling

IL12 signalling and production in macrophages

NF-kB signalling

JUN

Jun oncogene

4.08E-03

−1.587

CD28 signalling in T helper cells

IL12 signalling and production in macrophages

Production of nitric oxide and reactive oxygen species

T-cell receptor signalling

iNOS signalling

IL8 signalling

IL10 signalling

PLCG1

phospholipase C, gamma 1

5.33E-03

−1.541

iCOS-iCOSL signalling in T-helper cells

PCK signalling in T-lymphocytes

Production of nitric oxide and reactive oxygen species

Phospholipase C signalling

IL15 signalling

PRKCQ

protein kinase C, theta

3.14E-03

−1.461

T-cell receptor signalling

CCR5 signalling in macrophages

Natural killer cells signalling

Apoptosis signalling

B-cell receptor signalling

PRKD3

protein kinase D3

6.26E-03

−1.440

Calcium-induced T-lymphocyte apoptosis

LPS stimulated MAPK signalling

CCR5 signalling in macrophages

CCR3 signalling in eosinophils

CXCR4 signalling

  1. The genes analysed here were used when comparing non-immunised mice to mice immunised with a combination of T-cell-epitope-containing peptides (T14 + T15 + T16)