Transcriptome profiling of gene expression during immunisation trial against Fasciola hepatica: identification of genes and pathways involved in conferring immunoprotection in a murine model

Table 1 Assessing macroscopic hepatic lesions in CD1 mice

Group	Treatment	Lesion score (mean ± SEM)	Reduction (%)
1	Untreated uninfected
2	Infected	12.0 ± 1.5
3	Adjuvant treated	9.3 ± 1.8	22
4	B6 + T14	8.3 ± 1.8	31
5	B1 + B5 + B6	10.3 ± 1.6	14
6	T14 + T15 + T16	6.6 ± 0.6	45*
7	B1 + B2 + B5 + B6 + T14 + T15 + T16	7.3 ± 1.3	39*

The mice were immunised with combinations of synthetic peptides containing B- and T-cell epitopes using the ADAD vaccination system which had been orally challenged with 7 F. hepatica metacercariae
*p < 0.05 compared to infected controls

ISSN: 1471-2334