Fig. 4

The most representative signalling pathways and their associated up- and down-regulated genes are represented. The fold change of each gene is shown in parenthesis. The significance (−log p value) of each signalling pathway is also indicated by the scale to the right of the graph. Signalling pathway analysis was done only in the group of mice immunised with the combination of peptides containing T-cell epitopes (T14, T15, T16). Red and green squares represent genes belonging to each signalling pathway, whereas gray squares indicate absence of those genes in that pathway