Cocaine/crack use is not associated with fibrosis progression measured by AST-to-Platelet Ratio Index in HIV-HCV co-infected patients: a cohort study

Table 3 Multivariate analysis of cocaine/crack use and liver fibrosis progression

	Recent cocaine/crack use
	HR	95% CI
Time independent variables (at baseline)
Cocaine/crack use ever at baseline	0.96	0.58, 1.57
Baseline age (per 10 years)	1.04	0.86, 1.27
Female sex	1.45	1.04, 2.01
Baseline HCV infection duration (per 5 years)	1.00	0.92, 1.10
Baseline ln (APRI)	2.84	1.94, 4.16
Time updated variables
Recent cocaine/crack use	0.88	0.63, 1.25
Recent other drug use^a	1.07	0.77, 1.49
Current alcohol abuse^b	1.63	1.09, 2.42
CD4 count (per 100 cells/μL)	0.90	0.84, 0.96

^aHeroin and opiates, steroids, methylphenidate, hallucinogens (PCP, LSD), benzodiazepine, barbiturates, methamphetamine, amphetamine, other
^bDefined as >6 drinks at least once a month and >2 drinks on a typical day when drinking

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