From: Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study
Univariate Model | Multivariate Model | |||
---|---|---|---|---|
Risk factors | Hazard ratio (95% Confidence interval) | P-value | Hazard ratio (95% Confidence interval) | P-value |
Age < 35 years | 0.51 (0.29-0.87) | 0.014 | 0.91 (0.48-1.73) | 0.782 |
Female gender | 1.68 (1.01-2.80) | 0.045 | 1.65 (0.86-3.16) | 0.132 |
African ethnicity | 1.29 (0.77-2.15) | 0.366 | ||
Homo-bisexuel orientation | 0.28 (0.13-0.59) | 0.0003 | 0.90 (0.34-2.34) | 0.827 |
Natremia < 135 mmol/l | 3.94 (2.30-6.74) | <0.0001 | 1.03 (0.54-1.97) | 0.935 |
AIDS | 8.83 (5.18-15.06) | <0.0001 | 5.24 (2.59-10.62) | <0.0001 |
CD4 cell count < 350/μl | 11.71 (4.66-29.43) | <0.0001 | 6.58 (1.89-23.06) | 0.003 |
HIV viral load > 100 000 copies/ml | 3.36 (1.87-6.03) | <0.0001 | 1.15 (0.56-2.37) | 0.702 |
Hepatitis B | 0.23 (0.032-1.71) | 0.172 | ||
Hepatitis C | 2.54 (1.15-5.60) | 0.0259 | 2.70 (1.172-6.23) | 0.02 |
Fib4 score > 3.25 | 3.84 (1.95-7.55) | <0.0001 | 1.69 (0.77-3.74) | 0.192 |
Anemia | 4.30 (2.95-6.27) | <0.0001 | 1.15 (0.75-2.84) | 0.263 |
Hyperlipidemia | 0.93 (0.54-1.59) | 0.892 | ||
Diabetes mellitus | 4.22 (1.96-9.11) | 0.0011 | 2.07 (0.88-4.85) | 0.096 |
Inclusion period 1998-2004 | 2.54 (1.52-4.25) | 0.0004 | 1.32 (0.72 – 2.42) | 0.372 |