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Table 2 Outcomes in hyponatremic and normonatremic patients

From: Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study

Characteristics Total (N = 1196) Na < 135 mmol/l (N = 177) Na ≥ 135 mmol/l (N = 1019) P-value
Combined antiretroviral therapy (n) 845 (70.6%) 130 (73.4%) 715 (70.2%) 0.421
Follow-up (months)a 36.0 (9.0-80.0) 41.0 (4.0-115.0) 35.0 (10.0-77.0) 0.554
Loss to follow-up/100 patient-years (95% CI) 8.2 (7.5-9.1) 8.4 (7.4-9.1) 8.2 (6.5-10.6) 0.870
Deaths (n) 63 (5.3%) 24 (13.5%) 39 (3.8%) <0.0001
Death rate/1000 patient-years (95% CI) 12.5 (9.6-16.0) 28.3 (18.1-42.2) 9.33 (6.6-12.7) <0.0001
Hospitalization rate/1000 patient-years (95% CI) 440 (422–458) 785 (725–845) 370 (252–388) <0.0001
Mean number of hospitalizations per patient (n)b 2.2 ± 4.9 4.3 ± 9.5 1.8 ± 3.3 <0.0001
Median time to death (months)a 12.0 (3.0-34.0) 6.0 (2.0-22.5) 14.0 (4.0-39.0) 0.169
Median time to first hospitalization (months)a,c 12.0 (2.0-28.0) 2.0 (0.0-12.0) 13.0 (2.0-29.0) 0.0012
  1. amedian (interquartile range)
  2. bmean ± standard deviation
  3. cexcluding patients hospitalized at first contact