Fig. 1

TLR7 expression remains compromised in HepG2.2.15 cell lines. The expressions are significantly re-established on viral elimination. TLR7 expression of HBV infected subjects is downregulated compared to disease control steatosis patients and is also inversely related to the HBV DNA load in liver biopsy samples. a TLR7 mRNA expression of HepG2.2.15 cells is regained on treatment with Lamivudine, a potent nucleoside analog reverse transcriptase inhibitor, at different doses (20, 50 and 100μM). a TLR7 mRNA expression of HepG2 cells taken as control after treatment with Lamivudine shows no change. b TLR7 expression in HepG2.2.15 cells on treatment with different doses of Lamivudine. b HBV DNA viral load is suppressed on treatment of Lamivudine in a dose dependent manner. c The mean TLR7 expression of the control subjects was arbitrarily set as 1. The fold change of TLR7 expression in each of the patients was then evaluated. Increased TLR7 expression of liver biopsy specimen of control subjects with steatosis (LB_1-6) compared to HBV infected patients (LB7_18) along with clinical and virological parameters of the patients. Box and Whisker Plot was used to score the TLR7 expression. d Viral and clinical parameters of the patients