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Table 1 Baseline characteristics

From: Cost-effectiveness of antibiotic treatment strategies for community-acquired pneumonia: results from a cluster randomized cross-over trial

  Beta-lactam monotherapy (N = 656) Beta-lactam/macrolide (N = 739) Fluoroquinolone monotherapy (N = 888)
Median age (IQR) 70.6 (60.6–79.4) 70.7 (59.1–80.3) 71.0 (59.6–79.4)
Male gender 381 (58.1%) 431 (58.3%) 505 (56.9%)
Elderly home 32 / 644 (5.0%) 38 / 727 (5.2%) 41 / 878 (4.7%)
Hospitalization past 12 months 271 / 653 (41.5%) 298 / 722 (41.3%) 351 / 881 (39.8%)
Median number of comorbidities (IQR) a 1 (0–2) 1 (0–2) 1 (1–2)
Immunocompromised b 147 (22.4%) 173 (23.4%) 213 (24.0%)
Median CURB-65 score (IQR) d 1 (1–2) 1 (1–2) 1 (1–2)
Day-28 questionnaire received 276 (42.1%) 253 (34.2%) 376 (42.3%)
Reports paid work 51 / 246 (20.7%) 45 / 233 (19.3%) 78 / 342 (22.8%)
Reports volunteer work 23 / 245 (9.4%) 32 / 234 (13.7%) 35 / 340 (10.3%)
  1. Data are reported as N (%) unless otherwise indicated. IQR: inter quartile range
  2. a Reported comorbidities include chronic cardiovascular disease, heart failure, cerebrovascular disease, asthma, COPD, other chronic pulmonary disease, HIV/AIDS, diabetes mellitus, haematological malignanciesc, solid organ malignanciesc, chronic renal failure requiring dialysis, nephrotic syndrome, organ or bone marrow transplantation, alcoholism, chronic liver disease and functional or anatomic asplenia
  3. bPatients were categorized as immunocompromised if any of the following conditions applied: HIV/AIDS, haematological malignancies#, solid organ malignanciesc, chronic renal failure requiring dialysis, nephrotic syndrome, organ or bone marrow transplantation, or receipt of immunosuppressive therapy (for corticosteroids this required at least 0.5 mg/kg/day prednisolone or equivalent dosage for a minimum of 14 days)
  4. c Having received or been eligible for chemotherapy or radiotherapy in the past 5 years
  5. d The CURB-65 score is calculated by assigning 1 point each for confusion, uraemia (blood urea nitrogen ≥20 mg per deci- liter), high respiratory rate (≥30 breaths per minute), low systolic blood pressure (<90 mm Hg) or diastolic blood pres- sure (≤60 mm Hg), and an age of 65 years or older, with a higher score indicating a higher risk of death within 30 days