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Fig. 7 | BMC Infectious Diseases

Fig. 7

From: Early rising asexual parasitaemia in Nigerian children following a first dose of artemisinin-based combination treatments of falciparum malaria

Fig. 7

Features of molecular, time course, and release kinetics of asexual parasitaemia in age-, pre-treatment parasitaemia- and same treatment-matched malarious children with (1) and without (2) early rising asexual parasitaemia after first dose of dihydroartemisinin-piperaquine. Panel a shows increase in parasite clones from one to two and maximum parasite DNA band intensity 2 h post-initiation of treatment followed by decreasing intensity after 6 h. Parasite DNA clearance time was 48 h. Panel b shows stable number of clones (two in all) pre- and post-initiation of treatment and no change in DNA band intensity in the first 6 h followed by decrease in intensity. Parasite DNA clearance time was 24 h. Panel c shows peak parasitaemia at 2 h coincides with maximum DNA band intensity in Panel a. Panel d shows decreasing parasitaemia parallels DNA band intensity in Panel b. Panel e shows release kinetics estimated by method of residuals (lag time, half-time, and rate constant of 0.2 h, 0.5 h and 1.5 h−1, respectively, and monoexponential terminal elimination half-time of 2.3 h. Panel f shows only monoexponential terminal elimination half time of 1.7 h

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