Monophylogenetic HIV-1C epidemic in Ethiopia is dominated by CCR5-tropic viruses–an analysis of a prospective country-wide cohort

Table 2 Baseline tropism predicted by the geno2pheno clinical and clonal models, respectively, at the fpr10% level

	Clinical model FPR 10%				Clonal model FPR 10%				Concordance between clinical and clonal models^a
	R5	X4	R5/X4	p-value*	R5	X4	R5/X4	p-value*	R5-R5	R5-X4	X4-R5	X4-X4	p-value**
Number (%)	285 (81)	60 (17)	7 (2)		291 (82.7)	50 (14.2)	11 (3.1)		245 (69.6)	40 (11.4)	46 (13.0)	21 (6.0)
CD4 cells/ul median (IQR)	132 (76–193)	41 (21–98)	130 (107–220)	<0.001	125 (67–189)	89 (42–140)	160 (72–177)	0.08	135 (77–196)	127 (74–188)	55 (21–128)	70 (22–91)	<0.001
VL median (IQR)	5.3 (4.8–5.8)	5.4 (5.1–5.8)	5.3 (4.4–5.7)	0.18	5.4 (4.9–5.8)	5.4 (5–5.9)	5.4 (4.7–5.7	0.50	5.3 (4.8–5.8)	5.4 (5.1–5.9)	5.3 (4.4–5.7)	5.8 (5.3–5.9)	0.170

*Mann-Whitney U-Test; **Kruskal Wallis Test; ^aR5-R5: both models predicted R5 virus; R5-X4: clinical model predicted R5 virus and clonal model predicted X4 virus; X4-R5: clinical model predicted X4 virus and clonal model predicted R5 virus; X4-X4: both models predicted X4 virus. VL: viral load (copies/ml)