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Table 2 Baseline tropism predicted by the geno2pheno clinical and clonal models, respectively, at the fpr10% level

From: Monophylogenetic HIV-1C epidemic in Ethiopia is dominated by CCR5-tropic viruses–an analysis of a prospective country-wide cohort

 

Clinical model FPR 10%

Clonal model FPR 10%

Concordance between clinical and clonal modelsa

R5

X4

R5/X4

p-value*

R5

X4

R5/X4

p-value*

R5-R5

R5-X4

X4-R5

X4-X4

p-value**

Number (%)

285 (81)

60 (17)

7 (2)

 

291 (82.7)

50 (14.2)

11 (3.1)

 

245 (69.6)

40 (11.4)

46 (13.0)

21 (6.0)

 

CD4 cells/ul median (IQR)

132 (76–193)

41 (21–98)

130 (107–220)

<0.001

125 (67–189)

89 (42–140)

160 (72–177)

0.08

135 (77–196)

127 (74–188)

55 (21–128)

70 (22–91)

<0.001

VL median (IQR)

5.3 (4.8–5.8)

5.4 (5.1–5.8)

5.3 (4.4–5.7)

0.18

5.4 (4.9–5.8)

5.4 (5–5.9)

5.4 (4.7–5.7

0.50

5.3 (4.8–5.8)

5.4 (5.1–5.9)

5.3 (4.4–5.7)

5.8 (5.3–5.9)

0.170

  1. *Mann-Whitney U-Test; **Kruskal Wallis Test; aR5-R5: both models predicted R5 virus; R5-X4: clinical model predicted R5 virus and clonal model predicted X4 virus; X4-R5: clinical model predicted X4 virus and clonal model predicted R5 virus; X4-X4: both models predicted X4 virus. VL: viral load (copies/ml)