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Table 3 Characteristics of blood streams infections in newly diagnosed myeloma patients

From: Risk factors and characteristics of blood stream infections in patients with newly diagnosed multiple myeloma

Serial number BSI after ICT ICT regimen Catheter type Definite CRIb Pathogen Empirical antibiotics Early death
(< 100day)
Nosocomial BSIa
 1 (90) - - - - Coagulase-negative Staphylococcus species Ceftazidime/isepamicin Y
 2 (215) Y Thalidomide/dexamethasone - - Coagulase-negative Staphylococcus species Ceftazidime -
 3 (79) Y VAD Implanted port Y Coagulase-negative Staphylococcus species
Klebsiella pneumoniae
Teicoplanin/isepamicin Y
 4 (27) - MP - - Klebsiella pneumoniae Cefepime -
 5 (62) Y MPT Non-tunneled CVC Y Klebsiella pneumoniae Ciprofloxacin
- > Imipenem/teicoplanin
Y
 6 (78) - - - - Escherichia coli   Y
 7 (198) Y VAD Non-tunneled CVC - Escherichia coli Cefuroxime/clindamycin Y
 8 (168) Y VAD/thalidomide Non-tunneled PICC - Escherichia coli Imipenem/vancomycin/amikin Y
 9 (175) Y VAD - - Escherichia coli Cefuroxime/metronidazole -
 10 (150) Y VAD - - Enterobacter gergoviae Oxacillin -
 11 (14) Y VAD Implanted port - Enterobacter cloacae   -
 12 (94) - VAD Non-tunneled CVC - Pseudomonas Aeruginosa Cefepime Y
 13 (115) Y VAD Implanted port - Proteus mirabilis Levofloxacin -
 14 (69) Y VAD - - Salmonella Enteritidis group D Ceftazidime Y
 15 (114) Y VAD Non-tunneled CVC - Staphylococcus aureus   -
 16 (71) - - Non-tunneled CVC Y Serratia marcescens   Y
 17 (61) Y MP Non-tunneled CVC - Yeast like-Trichosporon asahii Cefepime/azithromycin Y
 18 (18) Y VAD - - Yeast like-Candida albicans Ceftazidime/teicoplanin Y
Non-nosocomial BSI
 1 (221) - - - - Coagulase-negative Staphylococcus species Flomoxef -
 2 (41) Y VAD - - Coagulase-negative Staphylococcus species Piperacillin/tazobactam -
 3 (211) Y MP - - Coagulase-negative Staphylococcus species   -
 4 (205) - - - - Streptococcus Meropenem/vancomycin/metronidazole Y
 5 (137) - - - - Streptococcus pneumoniae   -
 6 (6) - MP - - Escherichia coli Cephalexin/isepamicin -
 7 (106) - VAD Non-tunneled CVC - Pseudomonas aeruginosa Cefoperazone -
 8 (46) Y MP Tunneled CVC
(Permcath)
- Lactobacillus species Moxifloxacin Y
  1. Abbreviations: BSI Blood stream infection, ICT Induction chemotherapy, CRI Catheter related infection, VAD Vincristine/doxorubicin/dexamethasone, MP Melphalan/prednisolone, MPT Melphalan/prednisolone/thalidomide, CVC Central venous catheter, PICC Peripherally inserted central catheter
  2. aNosocomial infection is defined as infection become evident 48 h or more after admission
  3. bDefinite CRI (catheter related infection) is defined as bacteremia/fungemia in a patient with an intravascular catheter with at least one positive blood culture obtained from a peripheral vein, clinical manifestations of infection (i.e., fever, chills, and/or hypotension), and no apparent source for the bloodstream infection except the catheter