| |
Univariate
|
Multivariate
|
|---|
|
Odds ratio
|
95% CI
|
P value*
|
Odds ratio
|
95% CI
|
P value*
|
|---|
|
Gender (female vs. male)
|
1.36
|
0.571–3.266
|
0.49
|
-
|
-
|
-
|
|
Age (≥ 65 vs. < 65)
|
1.48
|
0.591–3.681
|
0.40
|
-
|
-
|
-
|
|
Myeloma subgroup
|
|
IgG vs. Non-IgG
|
1.06
|
0.469–2.410
|
0.88
|
-
|
-
|
-
|
|
IgA vs. Non-IgA
|
1.12
|
0.472–2.646
|
0.80
| | | |
|
Immunoglobulin status
|
1.18
|
0.324–4.303
|
0.80
|
-
|
-
|
-
|
|
Severe Ig deficiencya vs. Others
| | | | | | |
|
ISS stage
|
|
III vs. I/II
|
3.54
|
1.365–9.203
|
<0.01*
|
2.69
|
1.003–7.190
|
0.049
|
|
ECOG PS
|
|
Score > 2 vs. 0–2
|
4.39
|
1.849–10.403
|
<0.01*
|
3.58
|
1.478–8.690
|
0.005
|
|
Hb (< 10 g/dL vs. ≥ 10 g/dL)
|
3.422
|
1.240–9.444
|
0.02*
|
-
|
-
|
-
|
|
Ca (> 12 mg/dL vs. < 12 mg/dL)
|
3.095
|
1.013–9.454
|
0.04*
|
-
|
-
|
-
|
|
Cr (≥ 2.0 mg/dL vs. < 2.0 mg/dL)
|
3.091
|
1.341–7.126
|
0.01*
|
-
|
-
|
-
|
|
ALC (< 1000/cumm vs. ≥ 1000/cumm)
|
1.251
|
0.527–2.968
|
0.61
| | | |
-
Abbreviations: IgG Immunoglobulin G, IgA Immunoglobulin A, Ig Immunoglobulin, ISS International Staging System, ECOG PS Eastern Cooperative Oncology Group Performance Status, Hb Hemoglobin, Ca Calcium; Cr Creatinine, ALC Absolute lymphocyte count
-
aSevere Ig deficiency: both of the non-myeloma immunoglobulin levels less than one-fourth of lower normal limit
- *Significant p < 0.05 in univariate models were entered in the Cox regression multivariate model using conditional backward analysis
