Fig. 2

Phylogenetic tree based on 1212 nucleotides of the large S-gene (pre-S1/pre-S2/S) of 699 strains representing all HBV genotypes. All 252 available genotype A sequences of the large S-gene of strains from different African countries were included in the analysis. The genotypes are indicated on the branches. The branch with 53 of the 58 A1 strains from this study and additional 7 strains from Rwanda and 21 strains from other African countries is enlarged. The strains sequenced in this study are shown in red. Strains obtained from GenBank are given with accession number and country of origin at the nodes. Strains with the 18 amino acid deletion in pre-S2 are marked with a red arrowhead at the node