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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Thymus activity measured by T-cell receptor excision circles in patients with different severities of respiratory syncytial virus infection

Fig. 1

TREC and lymphocyte counts in infants with active Respiratory syncytial virus disease, by disease severity. Note: Panels a and b: T-cell receptor excision circle (TREC) copy numbers and lymphocyte counts in peripheral blood according to disease severity. TREC counts are significantly lower in the severe disease group. Lymphocyte counts show a similar pattern, but this is not significant. Plots show mean counts with 95% confidence intervals. Panel c: Scatterplot of TREC vs. lymphocyte counts. There is a strong positive correlation between TREC counts and lymphocyte counts (p = 0.00001; R 2 = 0.371). Panel d: Because TREC counts were strongly correlated to lymphocyte counts, and lymphocyte counts showed a similar pattern to TRECs between groups, TREC counts were adjusted for lymphocytes using ANCOVA. Estimated marginal means with 95% confidence intervals for TREC copies are presented. The difference in TREC count between disease severities remains significant. Post-hoc testing identified the severe disease group as having a lower adjusted TREC count than mild and moderate disease subgroups (p = 0.07 and p = 0.007, respectively). There was no difference between mild and moderate groups

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