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Table 3 Cytokine production by splenocytea cultures from immunized BALB/c mice

From: Vaccination with toxofilin DNA in combination with an alum-monophosphoryl lipid A mixed adjuvant induces significant protective immunity against Toxoplasma gondii

Groups

Cytokine Production (pg/ml)b

IFN-γ

IL-4

IL-10

PBS

48.54 ± 2.40

38.79 ± 2.28

44.70 ± 2.70

Alum

49.58 ± 2.37

110.49 ± 10.38

123.45 ± 13.48

MPLA

218.30 ± 21.34

40.35 ± 2.34

51.46 ± 3.21

alum-MPLA

267.34 ± 24.35

78.34 ± 7.34

58.46 ± 5.34

pEGFP- toxofilin

607.29 ± 63.09*

37.61 ± 2.87

34.70 ± 3.04

alum-toxofilin

694.39 ± 88.64*

236.47 ± 24.05^

212.32 ± 30.27^

MPLA-toxofilin

3043.54 ± 350.72*#

93.58 ± 10.31

85.43 ± 9.72

alum-MPLA-toxofilin

3859.42 ± 380.67*#

103.43 ± 24.43

115.32 ± 30.31

  1. aSplenocytes from 3 mice per group two weeks after the final immunization
  2. bValues for IFN-γ at 96 h, IL-4 at 24 h, IL-10 at 72 h and are expressed as mean ± SD
  3. *Compared with PBS, alum, MPLA, aum-MPLA, P < 0.05
  4. #Compared with alum-toxofilin or pEGFP-toxofilin groups, P < 0.05
  5. ^Compared with other groups