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Table 3 Cytokine production by splenocytea cultures from immunized BALB/c mice

From: Vaccination with toxofilin DNA in combination with an alum-monophosphoryl lipid A mixed adjuvant induces significant protective immunity against Toxoplasma gondii

Groups Cytokine Production (pg/ml)b
IFN-γ IL-4 IL-10
PBS 48.54 ± 2.40 38.79 ± 2.28 44.70 ± 2.70
Alum 49.58 ± 2.37 110.49 ± 10.38 123.45 ± 13.48
MPLA 218.30 ± 21.34 40.35 ± 2.34 51.46 ± 3.21
alum-MPLA 267.34 ± 24.35 78.34 ± 7.34 58.46 ± 5.34
pEGFP- toxofilin 607.29 ± 63.09* 37.61 ± 2.87 34.70 ± 3.04
alum-toxofilin 694.39 ± 88.64* 236.47 ± 24.05^ 212.32 ± 30.27^
MPLA-toxofilin 3043.54 ± 350.72*# 93.58 ± 10.31 85.43 ± 9.72
alum-MPLA-toxofilin 3859.42 ± 380.67*# 103.43 ± 24.43 115.32 ± 30.31
  1. aSplenocytes from 3 mice per group two weeks after the final immunization
  2. bValues for IFN-γ at 96 h, IL-4 at 24 h, IL-10 at 72 h and are expressed as mean ± SD
  3. *Compared with PBS, alum, MPLA, aum-MPLA, P < 0.05
  4. #Compared with alum-toxofilin or pEGFP-toxofilin groups, P < 0.05
  5. ^Compared with other groups
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BMC Infectious Diseases

ISSN: 1471-2334

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