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Table 2 Comparison of LAMP, smear and culture methods for the diagnosis of pulmonary tuberculosis

From: Comparison of loop-mediated isothermal amplification assay and smear microscopy with culture for the diagnostic accuracy of tuberculosis

 

Culture+

Culture–

Se %(95% CI)

Sp %(95% CI)

PPV (%)

NPV (%)

κ

LAMP+

21

1

75(56.6–87.3)

98(89.5–99.6)

95.5

87.5

0.77

LAMP-

7

49

     

Smear+

22

1

78.6(60.5–89.8)

98(89.5–99.6)

95.6

89.1

0.797

Smear-

6

49

     

Smear +

Smear -

     

LAMP+

19

3

82.6(62.9–93)

94.5(85.2–98.1)

86.4

92.9

0.83

LAMP-

4

52

     

Culture + Smear +

Culture- Smear -

     

LAMP+

19

3

86.4(66.7–95.3)

94.6(85.4–98.2)

86.4

94.6

0.82

LAMP-

3

53

     

Culture + Smear-

Culture-Smear+

     

LAMP+

2

0

33.3(9.7–70)

100(20.7–100)

100

80

NA

LAMP -

4

1

     

LAMP+ Culture+

LAMP- Culture-

     

Smear +

19

4

90.4(71.1–97.4)

93(83.3–97.2)

82.6

96.4

0.82

Smear-

2

53

     
  1. Se Sensitivity, Sp Specificity, PPV Positive predictive value. NPV Negative predictive value, κ Kappa value. CI confidence interval