Table 1 Demographic and clinical features in HIV negative patients with cryptococcal meningitis (CM) and tuberculous meningitis (TBM)
Variables | CM (N=126) | TBM (N=105) | P-value |
|---|---|---|---|
Sex | |||
Male | 79(62.7%) | 57(54.3%) | 0.227 |
Female | 47(37.3%) | 48(45.7%) | |
Age (years) | |||
≤30 | 29(23.0%) | 54(51.4%) | <0.001 |
31–60 | 65(51.6%) | 35(33.3%) | |
>60 | 32(25.4%) | 16(15.2%) | |
Presenting symptoms and signs | |||
Headache | 118(96.7%) | 87(82.9%) | 0.012 |
Fever | 71(56.3%) | 72(68.6%) | 0.038 |
Vomiting | 71(56.3%) | 47(44.8%) | 0.263 |
Altered mentation | 51(40.5%) | 43(41.0%) | 0.524 |
Abnormal vision | 35(27.8%) | 12(11.4%) | 0.002 |
Cough | 7(5.6%) | 24(22.9%) | <0.001 |
Seizure | 14(11.1%) | 6(5.7%) | 0.111 |
Abnormal hearing | 14(11.1%) | 3(2.9%) | 0.014 |
Apopsychia | 6(4.8%) | 2(1.9%) | 0.208 |
Dyspnea | 5(4.0%) | 1(1.0%) | 0.155 |
Meningeal signs | 89(70.6%) | 68(64.8%) | 0.209 |
Pathological signs | 22(17.5%) | 23(21.9%) | 0.247 |
Underlying diseases, factors or complications | |||
Corticosteroid medication | 22(17.5%) | 6(5.7%) | 0.005 |
Pnumonary infection | 22(17.5%) | 13(12.4%) | 0.188 |
Hepatobiliary diseases | 15(11.9%) | 12(11.4%) | 0.539 |
Tuberculosis outside CNS | 12(9.5%) | 62(59.0%) | <0.001 |
Immune system disease | 11(8.7%) | 6(5.7%) | 0.269 |
Hypertension | 11(8.7%) | 3(2.9%) | 0.054 |
Diabetes mellitus | 13(10.3%) | 10(9.5%) | 0.510 |
Chronic lung disease | 6(4.8%) | 3(2.9%) | 0.348 |
Multiple organ dysfunction syndrome | 6(4.8%) | 1(1.0%) | 0.095 |
Renal transplantation | 4(3.2%) | 2(1.9%) | 0.431 |
Hematology disease | 3(2.4%) | 1(1.0%) | 0.382 |
Others | 13(10.2%) | 12(11.4%) | 0.571 |
None | 29(23.0%) | 20(19.0%) | 0.284 |
Time from onset of symptoms to treatment (d) | |||
0–30 | 48(38.1%) | 56(53.3%) | <0.001 |
31–60 | 47(37.3%) | 33(31.4%) | |
61–90 | 19(15.1%) | 13(12.4%) | |
>90 | 12(9.5%) | 3(2.9%) | |
Outcome Improved | 80(63.5%) | 81(77.1%) | 0.031 |
Worse/Died | 46(36.5%) | 24(22.9%) | |