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Table 1 Demographic and clinical features in HIV negative patients with cryptococcal meningitis (CM) and tuberculous meningitis (TBM)

From: Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study

Variables CM (N=126) TBM (N=105) P-value
Sex
 Male 79(62.7%) 57(54.3%) 0.227
 Female 47(37.3%) 48(45.7%)
Age (years)
 ≤30 29(23.0%) 54(51.4%) <0.001
 31–60 65(51.6%) 35(33.3%)
 >60 32(25.4%) 16(15.2%)
Presenting symptoms and signs
 Headache 118(96.7%) 87(82.9%) 0.012
 Fever 71(56.3%) 72(68.6%) 0.038
 Vomiting 71(56.3%) 47(44.8%) 0.263
 Altered mentation 51(40.5%) 43(41.0%) 0.524
 Abnormal vision 35(27.8%) 12(11.4%) 0.002
 Cough 7(5.6%) 24(22.9%) <0.001
 Seizure 14(11.1%) 6(5.7%) 0.111
 Abnormal hearing 14(11.1%) 3(2.9%) 0.014
 Apopsychia 6(4.8%) 2(1.9%) 0.208
 Dyspnea 5(4.0%) 1(1.0%) 0.155
 Meningeal signs 89(70.6%) 68(64.8%) 0.209
 Pathological signs 22(17.5%) 23(21.9%) 0.247
Underlying diseases, factors or complications
 Corticosteroid medication 22(17.5%) 6(5.7%) 0.005
 Pnumonary infection 22(17.5%) 13(12.4%) 0.188
 Hepatobiliary diseases 15(11.9%) 12(11.4%) 0.539
 Tuberculosis outside CNS 12(9.5%) 62(59.0%) <0.001
 Immune system disease 11(8.7%) 6(5.7%) 0.269
 Hypertension 11(8.7%) 3(2.9%) 0.054
 Diabetes mellitus 13(10.3%) 10(9.5%) 0.510
 Chronic lung disease 6(4.8%) 3(2.9%) 0.348
 Multiple organ dysfunction syndrome 6(4.8%) 1(1.0%) 0.095
 Renal transplantation 4(3.2%) 2(1.9%) 0.431
 Hematology disease 3(2.4%) 1(1.0%) 0.382
 Others 13(10.2%) 12(11.4%) 0.571
 None 29(23.0%) 20(19.0%) 0.284
Time from onset of symptoms to treatment (d)
 0–30 48(38.1%) 56(53.3%) <0.001
 31–60 47(37.3%) 33(31.4%)
 61–90 19(15.1%) 13(12.4%)
 >90 12(9.5%) 3(2.9%)
 Outcome Improved 80(63.5%) 81(77.1%) 0.031
 Worse/Died 46(36.5%) 24(22.9%)