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Table 4 Baseline characteristics of patients in the first validation cohort. The patients all received biopsy-included pretreatment evaluations between 2007-2009

From: Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors

  Values P a
Subject number 45  
Age 51.53 ± 10.30 <0.001
Gender   0.034
  Male 33 (73.33%)  
  Female 12 (26.67%)  
Liver Histology
 ISHAK Fibrosis Stages   <0.001
  1 7 (15.56%)  
  2 5 (11.11%)  
  3 13 (28.89%)  
  4 6 (13.33%)  
  5 10 (22.22%)  
  6 14 (31.11%)  
 Piecemeal necrosis   0.07
  0 10 (22.22%)  
  1 23 (51.11%)  
  2 6 (13.33%)  
  3 6 (13.33%)  
 Confluent necrosis   0.165
  0 40 (88.89%)  
  4 5 (11.11%)  
 Focal (spotty) lytic necrosis, apoptosis and focal inflammation   0.329
  1 14 (31.11%)  
  2 27 (60.00%)  
  3 4 (8.89%)  
 Portal inflammation   0.114
  0 2 (4.44%)  
  1 13 (28.89%)  
  2 6 (13.33%)  
  3 23 (51.11%)  
  4 1 (2.22%)  
 Viral serology
  HBV DNA (log10 IU/ml) 5.31 ± 1.68 <0.001
  HBsAg (log10 IU/ml) 2.79 ± 0.90 <0.001
 Hematology
  ALT (IU/L) 141.00 ± 124.94 0.087
  AST (IU/L) 91.29 ± 83.45 0.277
  Bilirubin (mg/dL) 0.90 ± 0.28 0.119
  Albumin (g/dL) 4.45 ± 0.28 0.196
  Gamma-glutamyltransferase (IU/L) 66.20 ± 65.26 0.626
  Platelet (1000/mm3) 179.36 ± 53.17 0.22
  Hemoglobin (g/dL) 14.69 ± 1.29 0.032
  1. a Compared with the model-construction cohort