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Table 3 Baseline characteristics of patients with HBV DNA below or above 106 IU/mL

From: Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors

  HBV DNA Low HBV DNA High P
Subject number 131 196  
Age 45.66 ± 11.62 43.24 ± 10.83 0.059
Gender
  Male 115 (87.79%) 165 (84.18%) 0.363
  Female 16 (12.21%) 31 (15.82%)  
Liver Histology
 ISHAK Fibrosis Stages
  0 2 (0.61%) 0 (0%) 0.164
  1 15 (11.45%) 25 (12.76%)  
  2 16 (12.21%) 35 (17.86%)  
  3 53 (40.46%) 57 (29.08%)  
  4 11 (8.40%) 22 (11.22%)  
  5 29 (22.14%) 45 (22.96%)  
  6 5 (3.82%) 12 (6.12%)  
 Piecemeal necrosis
  0 45 (34.35%) 56 (28.57%) 0.234
  1 68 (51.91%) 97 (49.49%)  
  2 15 (11.45%) 32 (16.33%)  
  3 3 (2.29%) 11 (5.61%)  
 Confluent necrosis
  0 126 (96.18%) 181 (92.35%) 0.368
  1 1 (0.76%) 5 (2.55%)  
  2 0 (0%) 2 (1.02%)  
  3 1 (0.76%) 0 (0%)  
  4 3 (2.29%) 7 (3.57%)  
  5 0 (0%) 1 (0.51%)  
 Focal (spotty) lytic necrosis, /apoptosis and focal inflammation
  0 0 (0%) 2 (1.02%) 0.001
  1 53 (40.46%) 40 (20.41%)  
  2 54 (41.22%) 107 (54.59%)  
  3 21 (16.03%) 46 (23.47%)  
  4 3 (2.29%) 1 (0.51%)  
 Portal inflammation
  0 4 (3.05%) 2 (1.02%) 0.142
  1 38 (29.01%) 39 (19.90%)  
  2 36 (27.48%) 67 (34.18%)  
  3 49 (37.40%) 74 (37.76%)  
  4 4 (3.05%) 13 (6.63%)  
  5 0 (0%) 1 (0.51%)  
 Viral serology
  HBV DNA (log10 IU/ml) 4.67 ± 1.22 7.48 ± 0.82 <0.001
  HBeAg positive 36 (27.48%) 110 (56.12%) <0.001
  HBsAg (log10 IU/ml) 2.83 ± 0.97 3.67 ± 0.83 <0.001
 Serum biochemistry
  ALT (IU/L) 161.20 ± 179.34 188.07 ± 168.45 0.175
  AST (IU/L) 86.41 ± 89.06 120.77 ± 138.86 0.007
  Bilirubin (mg/dL) 1.00 ± 0.50 0.97 ± 0.36 0.559
  Albumin (g/dL) 4.58 ± 0.28 4.54 ± 0.39 0.418
  Gamma-glutamyltransferase (IU/L) 56.79 ± 42.31 61.58 ± 49.84 0.505
  Platelet (1000/mm3) 189.09 ± 49.34 190.23 ± 50.96 0.84
  Hemoglobin (g/dL) 15.32 ± 1.34 15.12 ± 1.37 0.26