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Table 3 Baseline characteristics of patients with HBV DNA below or above 106 IU/mL

From: Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors

 

HBV DNA Low

HBV DNA High

P

Subject number

131

196

 

Age

45.66 ± 11.62

43.24 ± 10.83

0.059

Gender

  Male

115 (87.79%)

165 (84.18%)

0.363

  Female

16 (12.21%)

31 (15.82%)

 

Liver Histology

 ISHAK Fibrosis Stages

  0

2 (0.61%)

0 (0%)

0.164

  1

15 (11.45%)

25 (12.76%)

 

  2

16 (12.21%)

35 (17.86%)

 

  3

53 (40.46%)

57 (29.08%)

 

  4

11 (8.40%)

22 (11.22%)

 

  5

29 (22.14%)

45 (22.96%)

 

  6

5 (3.82%)

12 (6.12%)

 

 Piecemeal necrosis

  0

45 (34.35%)

56 (28.57%)

0.234

  1

68 (51.91%)

97 (49.49%)

 

  2

15 (11.45%)

32 (16.33%)

 

  3

3 (2.29%)

11 (5.61%)

 

 Confluent necrosis

  0

126 (96.18%)

181 (92.35%)

0.368

  1

1 (0.76%)

5 (2.55%)

 

  2

0 (0%)

2 (1.02%)

 

  3

1 (0.76%)

0 (0%)

 

  4

3 (2.29%)

7 (3.57%)

 

  5

0 (0%)

1 (0.51%)

 

 Focal (spotty) lytic necrosis, /apoptosis and focal inflammation

  0

0 (0%)

2 (1.02%)

0.001

  1

53 (40.46%)

40 (20.41%)

 

  2

54 (41.22%)

107 (54.59%)

 

  3

21 (16.03%)

46 (23.47%)

 

  4

3 (2.29%)

1 (0.51%)

 

 Portal inflammation

  0

4 (3.05%)

2 (1.02%)

0.142

  1

38 (29.01%)

39 (19.90%)

 

  2

36 (27.48%)

67 (34.18%)

 

  3

49 (37.40%)

74 (37.76%)

 

  4

4 (3.05%)

13 (6.63%)

 

  5

0 (0%)

1 (0.51%)

 

 Viral serology

  HBV DNA (log10 IU/ml)

4.67 ± 1.22

7.48 ± 0.82

<0.001

  HBeAg positive

36 (27.48%)

110 (56.12%)

<0.001

  HBsAg (log10 IU/ml)

2.83 ± 0.97

3.67 ± 0.83

<0.001

 Serum biochemistry

  ALT (IU/L)

161.20 ± 179.34

188.07 ± 168.45

0.175

  AST (IU/L)

86.41 ± 89.06

120.77 ± 138.86

0.007

  Bilirubin (mg/dL)

1.00 ± 0.50

0.97 ± 0.36

0.559

  Albumin (g/dL)

4.58 ± 0.28

4.54 ± 0.39

0.418

  Gamma-glutamyltransferase (IU/L)

56.79 ± 42.31

61.58 ± 49.84

0.505

  Platelet (1000/mm3)

189.09 ± 49.34

190.23 ± 50.96

0.84

  Hemoglobin (g/dL)

15.32 ± 1.34

15.12 ± 1.37

0.26