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Table 3 Outcome, management and laboratory findings in single virus infections

From: Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen

  RSV RV hMPV HCoV FLU HAdV HBoV PIV p-value
N = 331 single pathogens 200 30 23 24 21 14 10 9  
Hospitalization
 admission, n(%) 162(81.0) 22(73.3) 16(69.6) 10(41.7) 16(76.2) 10(71.4) 9(90.0) 7(77.8) 0.004a
 days, mean (SD) 4.4(2.8) 3.3(3.1) 3.2(1.5) 3.9(3.4) 2.9(2.7) 2.9(2.1) 3.2(1.9) 5.3(2.7) 0.014b
 median (IQR) 4.0 (4.0) 2.0(3.75) 3.0(2.0) 3.0(3.75) 2.0(1.75) 2.0(1.5) 3.0(1.5) 4.0(5.0)  
Therapy
 AB initiated, n(%) 75(37.5) 7(23.3) 7(30.4) 4(16.7) 7(33.3) 1(7.1) 4(40.0) 6(66.7) 0.029a,c
 AB no of days, mean (SD) 2.4(3.3) 1.4(2.7) 2.4(3.9) 1.5(3.6) 2.0(3.0) 0.5(1.9) 2.8(3.6) 3.7(3.3) 0.091b
 median (IQR) 0.0(7.0) 0.0(0.8) 0.0(7.0) 0.0(0.0) 0.0(5.0) 0.0(0.0) 0.0(7.0) 3.0(7.0)  
 Oxygen initiated,n(%) 106(53) 9(30) 9(39.1) 3(12.5) 6(28.6) 5(35.7) 7(60) 5(55.6) 0.062a,c
 Oxygen no of days, mean (SD) 2.4(2.7) 1.2(2.2) 1.5(1.7) 1.0(1.8) 0.9(1.5) 1.4(2.1) 1.6(1.3) 2.9(2.9) 0.052b
 median (IQR) 2.35(4.0) 0.0(2.5) 1.0(3.0) 0.0(2.3) 0.0(1.8) 0.5(2.5) 2.0(2.0) 3.0(5.0)  
 Nebulizationd initiated n(%) 63(31.5) 6(20) 6(26.1) 0(0) 3(14.3) 4(28.6) 6(60) 3(33.3) 0.086a,c
 Nebulizationd, no of days, mean (SD) 1.2(2.0) 0.7(1.5) 0.8(1.3) 0.0(0.0) 0.4(0.9) 1.4(2.1) 2.2(2.2) 1.3(1.6) 0.050b
 median (IQR) 0.0(2.0) 0.0(1.0) 0.0(1.75) 0.0(0.0) 0.0(0.0) 0.0(2.75) 2.0(3.0) 0.0(3.0)  
Laboratory
 CRP performed, n(%) 111(55.5) 16(33.0) 9(39.1) 14(58.3) 15(71.4) 7(50.0) 4(40.0) 2(22.2) 0.401a,c
 CRP max level, mean (SD), mg/L 23.1(25.4) 13.8(19.9) 71.0(117.7) 19.0(44.4) 16.6(18.8) 27.3(36.7) 23.7(26.3) 26.0(31.1) 0.440b
 median (IQR) 14.0(37.0) 5.0(25.5) 14.0(112.0) 0.0(14.5) 9.0(25.0) 7.0(63.0) 21.0(48) 26.0(44.0)  
 CRP > 40, n(%), mg/L 27(13.5) 2(6.7) 3(13.0) 2(8.3) 2(9.5) 2(14.3) 2(20.0) 1(11.1) 0.706a,c
 WBC performed, n(%) 26(13.0) 3(10.0) 1(4.3) 0(0.0) 8(38.1) 1(7.1) 1(10.0) 1(11.1) 0.028a,c
 WBC max level, mean (SD), 109/L 11.6 (4.5) 9.5 (2.4) 7.6 . 8.1 (2.9) 12.7 13.6 (0.3) 27.0 0.065b
 median (IQR) 11.1(6.1) 9.4 7.6(0) . 8.8(5.6) 12.7(0.0) 13.6(0.0) 27.0(0)  
  1. AB antibiotics, CRP complement reactive protein, WBC white blood count
  2. Significant differences are noted as bold (highest) versus italic (lowest) when possible
  3. a Pearson Chi-square test
  4. b Kruskal Wallis test
  5. c interpret with caution as any cell has a value <5
  6. d Nebulization with salbutamol and ipratropium bromide