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Table 2 Plasma onset presepsin levels and increase rates in 11 febrile neutropenia cases with identified pathogens (FN group) and 4 afebrile neutropenia cases (AFN group)

From: Plasma presepsin level is an early diagnostic marker of severe febrile neutropenia in hematologic malignancy patients

FN group

           

Case

Commobidity

Pathogen identified in blood culture

Baseline level

Onset level

Previous level

blood examination intervala

Increase rate

Onset /Baseline ratio

Blood cell counts at onset day (/μL)

Remarks

 

(pg/mL)

(pg/mL)

(pg/mL)

(day)

 

WBC

neutrophils

1

AML

E.coli

280

760

329

4

33%

2.71

300

3

pneumonia(ARDS) ▪ ICU stay

2

AML

K.pneumoniae

206

562

296

3

30%

2.73

200

0

bacteremia

3

ALL

K.pneumoniae

187

558

279

2

50%

2.98

200

0

bacteremia

4

MDS

K.pneumoniae

169

341

186

2

42%

2.02

200

0

bacteremia

5

ML

E.aerogenes

330

1810

330

4

112%

5.48

100

0

bacteremia

bacteremia

6

MM

B.fragilis

201

884

201

10

33%

4.4

<100

0

bacteremia + diverticulitis

Average (gram negatives)

  

229 ± 62.4

819 ± 520

  

50%

3.39 ± 1.29

   

7

ML

E.gallinarum

320

644

361

2

39%

2.01

<100

0

bacteremia + HPS

8

MM

S.epidermidis

116

503

234

2

57%

4.34

<100

0

bacteremia + CRBSI

9

MDS

S.hominis

169

460

151

4

51%

2.72

<100

0

bacteremia

10

AA

Bacillus sp.

106

275

106

4

40%

2.59

300

250

bacteremia + CRBSI

11

AML

B.cereus

333

217

211

2

1%

0.65

<100

0

bacteremia + meningitis

Average (gram positives)

  

209 ± 110.2

420 ± 174

  

38%

2.46 ± 1.33

   

Average (FN group)

  

220 ± 83.1

638 ± 437

  

44%

2.97 ± 1.33

   

AFN group

Case

Commobidity

Pathogen identified in blood culture

Baseline level

Onset levelb

Previous level

Blood examination intervala

Increase rate

Onset /Baseline ratio

Blood cell counts at onset day (/μL)

Remarks

 

(pg/mL)

(pg/mL)

(pg/mL)

(day)

 

WBC

neutrophils

12

AML

 

174

223

172

2

15%

1.28

400

48

 

13

AML

 

138

298

137

2

59%

2.16

100

0

 

14

MM

 

49

188

89

5

22%

3.84

100

0

 

15

ML

 

120

247

136

7

12%

2.06

100

0

 

Average (AFN group)

  

120 ± 52.5

239 ± 46.2

  

27%

2.33 ± 1.08

   
  1. Abbreviations: ARDS acute respiratory distress syndrome, CRBSI catheter related blood stream infection, HPS hemophagocytic syndrome, WBC white blood cell
  2. ablood examination interval denotes the interval between peak level and previous level (day)
  3. bin the AFN group, onset level denotes the highest value within one chemotherapy course