Skip to main content

Table 2 Plasma onset presepsin levels and increase rates in 11 febrile neutropenia cases with identified pathogens (FN group) and 4 afebrile neutropenia cases (AFN group)

From: Plasma presepsin level is an early diagnostic marker of severe febrile neutropenia in hematologic malignancy patients

FN group            
Case Commobidity Pathogen identified in blood culture Baseline level Onset level Previous level blood examination intervala Increase rate Onset /Baseline ratio Blood cell counts at onset day (/μL) Remarks
  (pg/mL) (pg/mL) (pg/mL) (day)   WBC neutrophils
1 AML E.coli 280 760 329 4 33% 2.71 300 3 pneumonia(ARDS) ▪ ICU stay
2 AML K.pneumoniae 206 562 296 3 30% 2.73 200 0 bacteremia
3 ALL K.pneumoniae 187 558 279 2 50% 2.98 200 0 bacteremia
4 MDS K.pneumoniae 169 341 186 2 42% 2.02 200 0 bacteremia
5 ML E.aerogenes 330 1810 330 4 112% 5.48 100 0 bacteremia
bacteremia
6 MM B.fragilis 201 884 201 10 33% 4.4 <100 0 bacteremia + diverticulitis
Average (gram negatives)    229 ± 62.4 819 ± 520    50% 3.39 ± 1.29    
7 ML E.gallinarum 320 644 361 2 39% 2.01 <100 0 bacteremia + HPS
8 MM S.epidermidis 116 503 234 2 57% 4.34 <100 0 bacteremia + CRBSI
9 MDS S.hominis 169 460 151 4 51% 2.72 <100 0 bacteremia
10 AA Bacillus sp. 106 275 106 4 40% 2.59 300 250 bacteremia + CRBSI
11 AML B.cereus 333 217 211 2 1% 0.65 <100 0 bacteremia + meningitis
Average (gram positives)    209 ± 110.2 420 ± 174    38% 2.46 ± 1.33    
Average (FN group)    220 ± 83.1 638 ± 437    44% 2.97 ± 1.33    
AFN group
Case Commobidity Pathogen identified in blood culture Baseline level Onset levelb Previous level Blood examination intervala Increase rate Onset /Baseline ratio Blood cell counts at onset day (/μL) Remarks
  (pg/mL) (pg/mL) (pg/mL) (day)   WBC neutrophils
12 AML   174 223 172 2 15% 1.28 400 48  
13 AML   138 298 137 2 59% 2.16 100 0  
14 MM   49 188 89 5 22% 3.84 100 0  
15 ML   120 247 136 7 12% 2.06 100 0  
Average (AFN group)    120 ± 52.5 239 ± 46.2    27% 2.33 ± 1.08    
  1. Abbreviations: ARDS acute respiratory distress syndrome, CRBSI catheter related blood stream infection, HPS hemophagocytic syndrome, WBC white blood cell
  2. ablood examination interval denotes the interval between peak level and previous level (day)
  3. bin the AFN group, onset level denotes the highest value within one chemotherapy course