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Table 2 HBsAg prevalence of acute and chronic liver disease patients in different regions of Ethiopia from 1984 to 2013

From: Hepatitis viruses in Ethiopia: a systematic review and meta-analysis

Sampling year Study area Study design Study Population HBsAg, n (%) Patients’ characterization and evaluation systema References
1984 A.Ababa Prospective longitudinal 304 30(9.9) Patients with acute or chronic hepatitis, some with malignant liver disease, mainly hepatocellular carcinoma (HCC) [45]
1989 A.Ababa Consecutive hospital patients 334 91(27.2) Based on clinical and histological diagnostic criteria; patients with chronic hepatitis (n = 114), cirrhosis (n = 208) and hepatocellular carcinoma (n = 112) [46]
1991 North Ethiopia Epidemic outbreak 423 54(12.8) Icteric patients hospitalized during HEV [47]
1992 A.Ababa Consecutive hospital patients 110 22(20.0) Consecutive acute hepatitis patients and 19 pregnant women who had HEV infection [48]
1995 A.Ababa Consecutive hospital patients 238 65(27.3) Patients with chronic hepatitis (n = 14), cirrhotic (n = 156) and HCC (n = 68) [49]
2011 A.Ababa Prospective consecutive hospital patients 120 43(35.8) Patients with chronic liver disease based on clinical history, ultrasound, and impaired liver function tests. [44]
2011 Gondar Retrospective 2684 386(14.4) Five year retrospective study on clinically suspected hepatitis patients from different wards of Gondar hospital [50]
2013 Bale Robe Retrospective 358 80(22.3) All patients with chronic hepatitis [51]
  1. aThe clinical diagnostic criteria for grouping patients as chronic liver disease patients were based on the presence of patient history of either clinical signs like ascites, hepatomegaly, and splenomegaly with other clinical features including jaundice, palmar erythema, clubbing, edema, axillary and pubic hair loss, Spider nevi, flapping tremors, drowsiness, confusion and coma. Ultrasound showing coarse hepatic texture, changes in liver size, increased portal vein diameter, and splenomegaly. Impaired liver function tests, including raised level of alanine aminotransferase (ALT)