Table 2 Markers of liver injury or fibrosis by viral hepatitis co-infection status

ALT

 Number with measurement available

514

231

91

63

899

 Measure above 19 U/L

269 (52.3)

195 (84.4)

60 (65.9)

52 (82.5)

576 (64.1)

 Measure above 41 U/L

64 (12.5)

122 (52.8)

18 (19.8)

11 (17.5)

215 (23.9)

DAIDS grading (ULN taken as 41 U/L)

  Grade 1, mild

33 (6.4)

72 (31.2)

9 (9.9)

10 (15.9)

124 (13.8)

  Grade 2, moderate

3 (0.6)

21 (9.1)

0

0

24 (2.7)

  Grade 3 or 4, severe /potentially life threatening

0

7 (3.0)

0

0

7 (0.8)

AST

 Number with measurement available

514

231

91

63

899

 Measure above ULN of 38 U/L

127 (24.7)

141 (61.0)

18 (19.8)

18 (28.6)

304 (33.8)

 DAIDS grading (ULN 38 U/L)

  Grade 1, mild

81 (15.8)

86 (37.2)

12 (13.2)

7 (11.1)

186 (20.7)

  Grade 2, moderate

2 (0.4)

25 (10.8)

0

4 (6.4)

31 (3.5)

  Grade 3 or 4, severe /potentially life threatening

1 (0.2)

4 (1.7)

0

0

5 (0.6)

APRI score

 Number with measure available

445

171

86

60

762

 Median APRI [IQR]

0.27 [0.17, 0.42]

0.55 [0.30, 0.92]

0.23 [0.17, 0.34]

0.30 [0.21, 0.43]

0.30 [0.18, 0.52]

  < 0.5 (no significant fibrosis)

358 (80.5)

81 (47.4)

74 (86.1)

48 (80.0)

561 (73.6)

 0.5- ≤ 1.5 (intermediate)

76 (17.1)

69 (40.4)

12 (14.0)

10 (16.7)

167 (21.9)

  > 1.5 (significant fibrosis)

11 (2.5)

21 (12.3)

0

2 (3.3)

34 (4.5)

FIB-4

 Number with measure available

444

171

86

60

761

 Median FIB-4 [IQR]

0.61 [0.39, 0.93]

0.88 [0.59, 1.47]

0.53 [0.36, 0.74]

0.68 [0.50, 0.90]

0.67 [0.42, 1.01]

  < 1.45 (no advanced fibrosis)

403 (90.8)

128 (74.9)

85 (98.8)

53 (88.3)

669 (87.9)

 1.45-3.25 (intermediate)

37 (8.3)

41 (24.0)

1 (1.2)

4 (6.7)

83 (10.9)

  > 3.25 (advanced fibrosis)

4 (0.9)

2 (1.2)

0

3 (5.0)

9 (1.2)