Skip to main content

Table 2 Microbiological eradication and clinical cure following levofloxacin treatment stratified by MIC (Enterobacteriaceae isolates, ME population)

From: Outcomes of high-dose levofloxacin therapy remain bound to the levofloxacin minimum inhibitory concentration in complicated urinary tract infections

Baseline levofloxacin MIC, μg/mL

Microbiological eradication, n/N (%)

Clinical cure, n/N (%)

≤0.015

9/10 (90.0)

10/10 (100)

0.03

120/126 (95.2)

124/126 (98.4)

0.06

38/40 (95.0)

37/40 (92.5)

0.125

9/11 (81.8)

10/11 (90.9)

0.25

6/8 (75.0)

8/8 (100)

0.5

14/17 (82.4)

17/17 (100)

1

5/6 (83.3)

6/6 (100)

2

1/1 (100)

0/1 (0)a

4

3/9 (33.3)

9/9 (100)

8

11/17 (64.7)

15/17 (88.2)

16

20/44 (45.5)

36/44 (81.8)

32

4/13 (30.8)

11/13 (84.6)

64

1/6 (16.7)

4/6 (66.7)

128

0/1 (0)

0/1 (0)

  1. ME microbiologically evaluable, MIC minimum inhibitory concentration, n number of isolates assigned to an outcome of eradication or clinical cure, N number of isolates at each levofloxacin MIC
  2. Four E. coli isolates were not retested to determine MIC end points and were excluded from this analysis. Five patients had 2 Enterobacteriaceae isolates identified at baseline. Four patients had a clinical response of cure, and 1 patient had a clinical response of failure. Clinical response for these patients was counted once for each isolate at its respective MIC
  3. a This isolate was present in combination with a second isolate that had a levofloxacin MIC of 16 μg/mL; the patient’s clinical response was failure