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Table 2 Microbiological eradication and clinical cure following levofloxacin treatment stratified by MIC (Enterobacteriaceae isolates, ME population)

From: Outcomes of high-dose levofloxacin therapy remain bound to the levofloxacin minimum inhibitory concentration in complicated urinary tract infections

Baseline levofloxacin MIC, μg/mL Microbiological eradication, n/N (%) Clinical cure, n/N (%)
≤0.015 9/10 (90.0) 10/10 (100)
0.03 120/126 (95.2) 124/126 (98.4)
0.06 38/40 (95.0) 37/40 (92.5)
0.125 9/11 (81.8) 10/11 (90.9)
0.25 6/8 (75.0) 8/8 (100)
0.5 14/17 (82.4) 17/17 (100)
1 5/6 (83.3) 6/6 (100)
2 1/1 (100) 0/1 (0)a
4 3/9 (33.3) 9/9 (100)
8 11/17 (64.7) 15/17 (88.2)
16 20/44 (45.5) 36/44 (81.8)
32 4/13 (30.8) 11/13 (84.6)
64 1/6 (16.7) 4/6 (66.7)
128 0/1 (0) 0/1 (0)
  1. ME microbiologically evaluable, MIC minimum inhibitory concentration, n number of isolates assigned to an outcome of eradication or clinical cure, N number of isolates at each levofloxacin MIC
  2. Four E. coli isolates were not retested to determine MIC end points and were excluded from this analysis. Five patients had 2 Enterobacteriaceae isolates identified at baseline. Four patients had a clinical response of cure, and 1 patient had a clinical response of failure. Clinical response for these patients was counted once for each isolate at its respective MIC
  3. a This isolate was present in combination with a second isolate that had a levofloxacin MIC of 16 μg/mL; the patient’s clinical response was failure