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Table 4 Clinical Characteristics of Avian Influenza A(H7N9) Case-Patients by Virus Circulation Wave

From: Comparison of the first three waves of avian influenza A(H7N9) virus circulation in the mainland of the People’s Republic of China

  Total (N,%) Wave 1 (n, %) Wave 2 (n, %) Wave 3 (n, %) P
Main symptoms at early stage (N1 = 76,N2 = 227,N3 = 169)
 Fever 445(94.3) 74(97.4) 213(93.8) 158(93.5) 0.444
 Cough 386(81.8) 54(71.1) 194(85.5) 138(81.7) 0.019
 Weakness 186(39.4) 29(38.2) 88(38.8) 69(40.8) 0.891
 Muscle soreness 107(22.7) 20(26.3) 53(23.4) 34(20.1) 0.532
 Othersa 170(36) 37(48.7) 70(30.8) 63(37.3) 0.018
Underlying medical conditions (N1 = 74,N2 = 226,N3 = 166) 242(51.9) 43(58.1) 118(52.2) 81(48.8) 0.408
 Cardiovascular and cerebrovascular disease 159(34.1) 29(39.2) 69(30.5) 61(36.8) 0.266
 Metabolic diseases 68(14.6) 12(16.2) 37(16.4) 19(11.5) 0.359
 Chronic lung disease 50(10.7) 12(16.2) 22(9.7) 16(9.6) 0.251
 Chronic liver diseases 32(6.9) 3(4.1) 20(8.9) 9(5.4) 0.241
 Hematological system diseases 14(3.0) 1(1.4) 9(4) 4(2.4) 0.441
 Cancer 10(2.1) 2(2.7) 6(2.7) 2(1.2) 0.580
 Rheumatic autoimmune disease 11(2.4) 5(6.8) 2(0.9) 4(2.4) 0.015
 Immunosuppressive state 12(2.6) 1(1.4) 5(2.2) 6(3.6) 0.529
 Chronic kidney diseases 16(3.4) 1(1.4) 6(2.7) 9(5.4) 0.186
 Nervous system or neuromuscular dysfunction 6(1.3) 0(0) 4(1.8) 2(1.2) 0.500
Complications (N1 = 71,N2 = 219,N3 = 162) 406(89.8) 64(90.1) 197(90) 145(89.5) 0.985
 Pneumonia 392(86.7) 64(90.1) 187(85.4) 141(87.0) 0.585
 Respiratory failure 311(68.8) 47(66.2) 144(65.8) 120(74.1) 0.195
 Acute Respiratory Distress Syndrome(ARDS) 298(65.9) 42(59.2) 141(64.4) 115(71) 0.171
 Hepatic insufficiency 193(42.7) 25(35.2) 90(41.1) 78(48.2) 0.148
 Renal insufficiency 152(33.6) 23(32.4) 68(31.1) 61(37.7) 0.391
 Septic shock 141(31.2) 14(19.7) 64(29.2) 63(38.9) 0.010
 Cardiac failure 124(27.4) 16(22.5) 49(22.4) 59(36.4) 0.006
 Neurologic complications 27(6.0) 2(2.8) 12(5.5) 13(8.0) 0.277
 Disseminated intravascular coagulation 25(5.5) 3(4.2) 9(4.1) 13(8.0) 0.222
 Rhabdomyalysis 17(3.8) 1(1.4) 6(2.7) 10(6.2) 0.115
 Failure of two or more organs 302(66.8) 45(63.4) 139(63.5) 118(72.8) 0.127
  1. N1: Number of individuals in Wave 1 who had clinical information, N2: Number of individuals in Wave 2 who had clinical information, N3: Number of individuals in Wave 3 who had clinical information
  2. aIncluding shortness of breath, chest distress, expectoration, nausea, vomiting, et al