Table 3 DEGs in plasma after HCV infection in clearance group compared to those in chronically infected group
DEGsa | Function | Fold difference | P value | FDR |
|---|---|---|---|---|
MIXL1 | Mix paired-like homeobox. Among its related pathways are Cardiac Progenitor differentiation and Adipogenesis. | 142.7 | 3.52E–07 | 0.00142576 |
SLC30A3 | Solute carrier family 30 (zinc transporter), member 3. Its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. | 23.8 | 5.32E–07 | 0.00142576 |
SFRP5 | Secreted frizzled-related protein 5. Its related pathways are Wnt signaling pathway (KEGG) (Wnt proteins are secreted morphogens that are required for basic developmental processes) and Non-Canonical Wnt Pathway. | 53.4 | 2.05E–06 | 0.00365475 |
AC007879.2 | Uncharacterized | 13.8 | 1.45E–05 | 0.00595947 |
AD000091.2 | Uncharacterized | 283.2 | 1.05E–05 | 0.00595947 |
C12orf44 | Autophagy related 101 | 18.9 | 8.91E–06 | 0.00595947 |
HNF1A-AS1 | HNF1A antisense RNA 1 affiliated with the antisense RNA class. | 48.4 | 1.32E–05 | 0.00595947 |
LBR | Lamin B receptor. Its related pathways are Metabolism and Metabolism. | 70.9 | 1.36E–05 | 0.00595947 |
MTMR1 | Myotubularin related protein 1. Its related pathways are Metabolism and Metabolism. | 20.4 | 1.44E–05 | 0.00595947 |
NLRP13 | NLR family, pyrin domain containing 13 | 10.9 | 5.86E–06 | 0.00595947 |
PPP1R3G | Protein phosphatase 1, regulatory subunit 3G. It is related to protein phosphatase binding and glycogen binding. | 82.1 | 1.25E–05 | 0.00595947 |
PRPSAP1 | Phosphoribosyl pyrophosphate synthetase-associated protein 1. This gene is related to magnesium ion binding and enzyme inhibitor activity. | 56.8 | 1.29E–05 | 0.00595947 |
RAB11FIP5 | RAB11 family interacting protein 5 (class I). Its related pathways are Endocytosis and Delta508-CFTR traffic / ER-to-Golgi in CF. | 53.4 | 1.01E–05 | 0.00595947 |
RP11-436F21.1 | Uncharacterized | 9.6 | 1.93E–05 | 0.00740049 |
C11orf95 | Chromosome 11 open reading frame 95. Diseases associated with C11orf95 include ependymoma and chondroid lipoma. | 119.4 | 2.56E–05 | 0.00913053 |
HOXD13 | Homeobox D13. This gene is related to sequence-specific DNA binding transcription factor activity and chromatin binding. | 96 | 3.07E–05 | 0.01028157 |
RP11-508M8.1 | Uncharacterized | 14.6 | 3.46E–05 | 0.0109017 |
CTC-504A5.1 | Affiliated with the ncRNA class | 9.9 | 3.82E–05 | 0.01135634 |
IRS4 | Insulin receptor substrate 4. Its related pathways are Signaling by GPCR and Insulin receptor signaling cascade. | 54.4 | 5.62E–05 | 0.01466991 |
MANEAL | Mannosidase, endo-alpha-like. It is related to hydrolase activity. | 14.7 | 5.95E–05 | 0.01466991 |
MCU | Mitochondrial calcium uniporter. It is related to calcium channel activity and uniporter activity. | 11.9 | 6.03E–05 | 0.01466991 |
SUV420H2_1 | Uncharacterized | 18.4 | 5.71E–05 | 0.01466991 |
SLC25A18 | Solute carrier family 25 (glutamate carrier), member 18. It is related to this gene include symporter activity. | 86.7 | 6.39E–05 | 0.01489091 |
GNAI1 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. Its related pathways are GPCR Pathway and GPCR Pathway. | 10.8 | 6.69E–05 | 0.01492573 |
ADPRHL1 | ADP-ribosylhydrolase like 1. It is related to magnesium ion binding and ADP-ribosylarginine hydrolase activity. | 7.3 | 9.39E–05 | 0.01676156 |
CMTM4 | CKLF-like MARVEL transmembrane domain containing 4. It is related to cytokine activity. | 16 | 9.17E–05 | 0.01676156 |
F10 | Coagulation factor X. it is related the pathways of Hemostasis and Formation of Fibrin Clot (Clotting Cascade). | 11.4 | 8.76E–05 | 0.01676156 |
LPAR1 | Lysophosphatidic acid receptor 1. Its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. | 9.6 | 8.50E–05 | 0.01676156 |
LYSMD4 | LysM, putative peptidoglycan-binding, domain containing 4 | 10.3 | 8.30E–05 | 0.01676156 |
RP11-886H22.1 | Uncharacterized | 9.3 | 9.38E–05 | 0.01676156 |
ATP12A | ATPase, H+/K+ transporting, nongastric, alpha polypeptide. It is related to the pathways of Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. | 10.2 | 1.22E–04 | 0.01943478 |
POU4F1-AS1 | RNF219 antisense RNA 1 | 8.1 | 1.23E–04 | 0.01943478 |
PRDM13 | PR domain containing 13. This gene related to methyltransferase activity. | 30.5 | 1.23E–04 | 0.01943478 |
ZXDA | Zinc finger, X-linked, duplicated A. it is related to sequence-specific DNA binding transcription factor activity and C2H2 zinc finger domain binding. | 45.3 | 1.17E–04 | 0.01943478 |
AC009495.4 | Uncharacterized | 8.9 | 1.59E–04 | 0.02368413 |
RP11–410N8.1 | Uncharacterized | 29.8 | 1.55E–04 | 0.02368413 |
ANKRD34B | Ankyrin repeat domain 34B | 10.4 | 2.00E–04 | 0.02675171 |
DPY19L3 | Dpy-19-like 3. It is related to transferase activity, transferring glycosyl groups. | 5.2 | 2.08E–04 | 0.02675171 |
LINC00609 | long intergenic non-protein coding RNA 609 | 8.9 | 2.08E–04 | 0.02675171 |
RP11–180P8.3 | Uncharacterized | 96.5 | 2.15E–04 | 0.02675171 |
RP11–492E3.2 | Uncharacterized | −8.3 | 2.05E–04 | 0.02675171 |
TLX3 | T-cell leukemia homeobox 3. Its related pathways are Transcriptional misregulation in cancer and SIDS Susceptibility Pathways. | 83.1 | 1.96E–04 | 0.02675171 |
ZFHX3 | Zinc finger homeobox 3. Its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. | 12.5 | 2.11E–04 | 0.02675171 |
SOHLH1 | Spermatogenesis and oogenesis specific basic helix-loop-helix 1. It is related to sequence-specific DNA binding transcription factor activity and protein dimerization activity. | 15.2 | 2.54E–04 | 0.03086759 |
SLC51A | Solute carrier family 51, alpha subunit. It is related the Bile secretion and Drug Induction of Bile Acid Pathway. | 7.6 | 2.60E–04 | 0.03093234 |
TCF15 | Transcription factor 15 (basic helix-loop-helix). It is related to ERK Signaling and ERK Signaling pathways. | 8.8 | 2.74E–04 | 0.03191743 |
RP11–118B18.1 | Uncharacterized | 6.5 | 3.08E–04 | 0.03504717 |
ATP6V1G2 | ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G2. A multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. | 23.3 | 3.68E–04 | 0.04059745 |
RP11–435M3.2 | Uncharacterized | 15.9 | 3.71E–04 | 0.04059745 |
C4orf32 | A Protein Coding gene | 4.4 | 4.10E–04 | 0.04218642 |
ZC3H8 | Zinc finger CCCH-type containing 8. It is related to sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. | 7 | 3.94E–04 | 0.04218642 |
ZXDB | A protein coding gene. It is related to nucleic acid binding. | 32.1 | 4.03E–04 | 0.04218642 |
CHST10 | Carbohydrate sulfotransferase 10. Its related pathways are Other types of O-glycan biosynthesis and Biological oxidations. | 6.6 | 4.38E–04 | 0.04421968 |
RP11–7F17.5 | Uncharacterized | −5.1 | 4.50E–04 | 0.04426996 |
TMEM52 | Transmembrane protein 52 | 108.9 | 4.55E–04 | 0.04426996 |
NEURL | A Protein Coding gene. It is related the pathways of Signaling by GPCR and Disease. | 6 | 4.68E–04 | 0.0447815 |
AP3B1 | A protein coding gene. It is related to the pathway of Lysosome and Clathrin derived vesicle budding. | 7.8 | 5.28E–04 | 0.04960697 |