Skip to main content

Table 2 Frequencies of HPV negative, HPV positive and failed samples considering all 499 samples, stratified on cytological categories

From: Quality assurance of human papillomavirus (HPV) testing in the implementation of HPV primary screening in Norway: an inter-laboratory reproducibility study

  All (n = 499) NILM (n = 354) ASC-US (n = 36) LSIL (n = 33) ASC-H/HSIL (n = 49) Unsatisfactory (n = 27) ASC-US or more severe (n = 118)
#pos (%) #neg (%) #failed (%) #pos (%) #neg (%) #failed (%) #pos (%) #neg (%) #failed (%) #pos (%) #neg (%) #failed (%) #pos (%) #neg (%) #failed (%) #pos (%) #neg (%) #failed (%) #pos (%) #neg (%) #failed (%)
Lab A 145 (29.1) 350 (70.1) 4 (0.8) 34 (9.6) 317 (89.6) 3 (0.8) 32 (88.9) 4 (11.1) 0 (0.0) 33 (100.0) 0 (0.0) 0 (0.0) 44 (89.8) 5 (10.2) 0 (0.0) 2 (7.4) 24 (88.9) 1 (3.7) 109 (92.4) 9 (7.6) 0 (0.0)
Lab B 145 (29.1) 346 (69.3) 8 (1.6) 34 (9.6) 314 (88.7) 6 (1.7) 33 (91.7) 3 (8.3) 0 (0.0) 31 (93.9) 0 (0.0) 2 (6.1) 44 (89.8) 5 (10.2) 0 (0.0) 2 (11.1) 24 (88.9) 0 (0.0) 108 (91.5) 8 (6.8) 2 (1.7)
Lab C 141 (28.3) 355 (71.1) 3 (0.6) 32 (9.0) 321 (90.7) 1 (0.3) 31 (86.1) 4 (11.1) 1 (2.8) 32 (96.8) 0 (0.0) 1 (3.0) 44 (89.8) 5 (10.2) 0 (0.0) 2 (7.4) 25 (92.6) 0 (0.0) 107 (90.7) 9 (7.6) 2 (1.7)
Lab D 146 (29.3) 353 (70.7) 0 (0.0) 35 (9.9) 319 (90.1) 0 (0.0) 32 (88.9) 4 (11.1) 0 (0.0) 33 (100.0) 0 (0.0) 0 (0.0) 44 (89.8) 5 (10.2) 0 (0.0) 2 (7.4) 25 (92.6) 0 (0.0) 109 (92.4) 9 (7.6) 0 (0.0)
% Overall Agreement 95.6 (93.8–97.2) 95.8 (93.5–97.7) 94.4 (86.1–100.0) 90.9 (78.8–100.0) 100.0 (100.0–100.0) 92.6 (81.5–100.0) 95.8 (92.4–99.2)
% Positive Agreement 90.8 (85.9–94.9) 79.4 (65.1–91.5) 93.9 (84.8–100.0) 90.9 (78.8–100.0) 100.0 (100.0–100.0) 66.7 (0.0–100.0) 95.5 (91.4–99.1)
Kappa 0.94 (0.92–0.97) 0.88 (0.80–0.93) 0.86 (0.52–1.00) n/a 1.0 0.78 (−0.03–1.00) 0.86 (0.71–0.97)
  1. Agreement statistics with 95% confidence intervals between the laboratories are shown
  2. NILM negative for intraepithelial lesion or malignancy, ASC-US atypical squamous cells of undetermined significance, LSIL low-grade squamous intraepithelial lesion, ASC-H atypical squamous cells, cannot exclude a high-grade lesion, HSIL high-grade squamous intraepithelial lesion