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Table 2 Sites of infection according to the underlying conditions in 63 paediatric cases of mucormycosis

From: Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries

Underlying conditions Dissemination Pulmonary/deep extension Cutaneous + soft tissue Sinus + sinoorbital Rhinocerebral
Haematological malignancies 12/29 (41.3a) 7/29 (24.1) 4/29 (13.7) 4/29 (13.7) 2/29 (6.8)
HSCTb 6/10 (60) 3/10 (30) 1/10 (10) 0 0
SOT 1/3 (33.3) 1/3 (33.3) 1/3 (33.3) 0 0
Other malignancies 2/4 (50) 1/4 (25) 0 0 1/4 (25)
Diabetes mellitus 0 0 1/3 (33.3) 1/3 (33.3) 1/3 (33.3)
Trauma/surgery 1/3 (33.3) 0 2/3 (66.6) 0 0
Other conditions 1/5 (20) 0 2/5 (40) 1/5 (20) 1/5 (20)
None 1/6 (16.6) 0 1/6 (16.6) 4/6 (66.6) 0
Total
 Number of cases (%) 24 (38.1) 12 (19) 12 (19) 10 (15.9) 5 (7.9)
 Mortality (%) 13/21 (61.9) 3/10 (30) 0/9 (0) 4/10 (40) 1/3 (33.3)
  1. HSCT hematopoietic stem cell transplantation, SOT solid organ transplantation
  2. a Numbers in parenthesis are percentages
  3. b In 10 patients (15.8%) mortality rates were not recorded due to lost to follow up
  4. Dissemination was defined as >1 non-contiguous locations of Mucorales infection
  5. Pulmonary infection was characterized as localized when it was only in the lung tissue and with deep extension when it extended to adjacent tissues, such as pleura and heart
  6. Sino-orbital refers to cases involving sinus and orbit, without extension to brain