Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries

Table 2 Sites of infection according to the underlying conditions in 63 paediatric cases of mucormycosis

Underlying conditions	Dissemination	Pulmonary/deep extension	Cutaneous + soft tissue	Sinus + sinoorbital	Rhinocerebral
Haematological malignancies	12/29 (41.3^a)	7/29 (24.1)	4/29 (13.7)	4/29 (13.7)	2/29 (6.8)
HSCT^b	6/10 (60)	3/10 (30)	1/10 (10)	0	0
SOT	1/3 (33.3)	1/3 (33.3)	1/3 (33.3)	0	0
Other malignancies	2/4 (50)	1/4 (25)	0	0	1/4 (25)
Diabetes mellitus	0	0	1/3 (33.3)	1/3 (33.3)	1/3 (33.3)
Trauma/surgery	1/3 (33.3)	0	2/3 (66.6)	0	0
Other conditions	1/5 (20)	0	2/5 (40)	1/5 (20)	1/5 (20)
None	1/6 (16.6)	0	1/6 (16.6)	4/6 (66.6)	0
Total
Number of cases (%)	24 (38.1)	12 (19)	12 (19)	10 (15.9)	5 (7.9)
Mortality (%)	13/21 (61.9)	3/10 (30)	0/9 (0)	4/10 (40)	1/3 (33.3)

HSCT hematopoietic stem cell transplantation, SOT solid organ transplantation
^a Numbers in parenthesis are percentages
^b In 10 patients (15.8%) mortality rates were not recorded due to lost to follow up
Dissemination was defined as >1 non-contiguous locations of Mucorales infection
Pulmonary infection was characterized as localized when it was only in the lung tissue and with deep extension when it extended to adjacent tissues, such as pleura and heart
Sino-orbital refers to cases involving sinus and orbit, without extension to brain

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