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Table 6 Predictors of hospital length of stay during diagnosis and treatment of active TB, stratified by timing of hospitalization, Montreal, January 1996 -- May 2007

From: Predictors of hospitalization of tuberculosis patients in Montreal, Canada: a retrospective cohort study

 

Initial hospitalizations

(n = 1006)

Hospitalizations during treatment (n = 206)

Characteristics

Crude HR

(95% CI)

Adjusted HRa,b

(95% CI)

Crude HR

(95% CI)

Adjusted HRa

(95% CI)

Sex

 Male

1.01 (0.89–1.14)

-

1.29 (0.78–2.11)

-

 Female

1.00

 

1.00

 

Age in yearsc

   

0.99 (0.98–1.00)

 log(LOS) ≤ 2.5

1.02 (1.02–1.03)

1.02 (1.02–1.03)

-

-

 log(LOS) > 2.5

0.96 (0.96–0.96)

0.96 (0.96–0.96)

-

-

Had provincial health insurance #

 Yes

0.96 (0.81–1.14)

-

1.15 (0.63–2.10)

-

 No

1.00

 

1.00

 

Country of birth

 Canada

0.68 (0.55–0.83)

-

0.80 (0.47–1.37)

-

 Foreign, low-moderate incidence

0.88 (0.74–1.04)

 

0.57 (0.33–0.98)

 

 Foreign, high incidence country

1.00

 

1.00

 

Immigration, years since arrival

 Foreign-born, unknown arrival date

1.47 (1.13–1.91)

-

0.57 (0.28–1.15)

-

 15 or more years

1.11 (0.92–1.35)

 

0.70 (0.34–1.44)

 

 3–14 years

1.50 (1.26–1.79)

 

0.85 (0.50–1.42)

 

 0–2 years

1.42 (1.17–1.71)

 

1.15 (0.58–2.28)

 

 Canadian-born

1.00

 

1.00

 

Homeless

 

-

 

-

 Yes

0.89 (0.56–1.40)

 

0.26 (0.11–0.63)

 

 No

1.00

 

1.00

 

Cancer

 

-

  

 Yes

0.82 (0.55–1.23)

 

1.42 (0.89–2.26)

-

 No

1.00

 

1.00

 

Diabetes

 

-

  

 Yes

0.92 (0.76–1.11)

 

1.05 (0.63–1.75)

-

 No

1.00

 

1.00

 

HIV

 Positive

0.83 (0.70–0.99)

0.77 (0.66–0.90)

0.93 (0.59–1.47)

0.61 (0.40–0.91)

 Negative or unknown

1.00

1.00

1.00

1.00

Renal disease

 Yes

0.55 (0.43–0.70)

0.59 (0.46–0.75)

0.45 (0.21–0.95)

0.58 (0.31–1.10)

 No

1.00

1.00

1.00

1.00

Liver disease

 Yes

0.79 (0.66–0.94)

-

1.62 (0.99–2.66)

-

 No

1.00

 

1.00

 

Ever substance abuse

 Yes

0.91 (0.79–1.05)

-

0.88 (0.58–1.33)

-

 No

1.00

 

1.00

 

Number of co-morbidities

 2 or more

0.65 (0.56–0.75)

-

0.74 (0.44–1.25)

-

 1

0.85 (0.73–1.00)

 

0.69 (0.36–1.31)

 

 0

1.00

 

1.00

 

Ever smoker

 Yes

0.84 (0.74–0.96)

-

0.91 (0.59–1.40)

-

 No

1.00

 

1.00

 

TB diagnosis

 Pulmonary, Smear+

0.61 (0.51–0.72)

0.64 (0.54–0.77)

1.51 (0.84–2.69)

1.26 (0.78–1.99)

 Pulmonary, Smear-

089 (0.73–1.09)

1.02 (0.84–1.26)

1.50 (0.80–2.83)

1.81(1.07–3.04)

 Extra-pulmonary

1.00

1.00

1.00

1.00

Cavitary TB

 Yes

0.92 (0.90–1.05)

-

1.91 (1.13–3.25)

-

 No

1.00

 

1.00

 

Miliary TB

 Yes

0.83 (0.63–1.10)

-

1.13 (0.70–1.83)

-

 No

1.00

 

1.00

 

Any pulmonary TB-related symptoms

 Yes

0.65 (0.50–0.85)

0.70 (0.55–0.90)

0.61 (0.42–0.90)

0.46 (0.27–0.80)

 No

1.00

1.00

1.00

1.00

Any systemic TB-related symptoms

 Yes

0.80 (0.69–0.93)

-

1.16 (0.60–2.26)

-

 No

1.00

 

1.00

 

Multidrug or poly-drug resistance

 Yes

0.65 (0.50–0.85)

0.44 (0.32–0.60)

0.62 (0.28–1.39)

0.28 (0.12–0.66)

 No

1.00

1.00

1.00

1.00

Teaching hospital

 Yes

0.86 (0.75–0.99)

0.81 (0.71–0.92)

0.99 (0.62–1.59)

-

 No

1.00

1.00

1.00

 
  1. IQR interquartile range, LOS length of stay, HR hazard ratio, CI confidence interval
  2. aModels adjusted for all reported variables
  3. bCox Proportional Hazard model is modeling the time to discharge; a hazard ratio of less than one indicates a longer LOS (ie. A HR for multidrug or poly-drug resistance = 0.45 can be interpreted as: the rate of discharge from hospital is 55% slower for patients with drug resistance compared to those without drug resistance)
  4. cGiven strong evidence that proportional hazards assumptions did not hold for age (lines crossed in the log-log plot), we included an interaction term in the model of age (continuous, in years) multiplied by the LOS. This interaction term indicates that the effect of age was not constant throughout the length of stay