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Table 1 Univariate analysis of risk factors for infection-related death in 127 patients with infections caused by CRE

From: A prospective study of treatment of carbapenem-resistant Enterobacteriaceae infections and risk factors associated with outcome

Characteristics Total (n = 127) Survivors (n = 83) Deaths (n = 44) RR (95 % CI) P
Patient related
 Age (years) (SD) 55.7(18)     
 Age over 60 (%) 57(44.9) 32(38.5) 25(56.8) 1.29(0.99–1.70) 0.03
 Male (%) 88(69.3) 59(71.0) 29(65.9) 0.91(0.68–1.22) 0.34
 ICU (%) 98(77.2) 60(72.3) 38(86.4) 1.29(1.01–1.65) 0.054
 Comorbidities (%) 97(76.4) 67(73.6) 30(83.3) 1.39(1.10–1.75) 0.01
  =1 23(18.1) 19(22.9) 4(9,0) 0.74(0.58–0.94) 0.04
  =2 32(25.2) 17(20.5) 15(34.0) 1.30(0.92–1.85) 0.07
  3 or more 42(33.0) 22(26.5) 20(45.4) 1.37(0.99–1.88) 0.02
 Surgery (%) 59(46.5) 41(49.4) 18(40.9) 0.88(0.69–1.14) 0.23
 Dialyses (%) 45(35.4) 18(21.7) 27(61.4) 1.98(1.36–2.88) 0.0001
 Previous colonization (%) 76(59.8) 50(60.2) 26(59.0) 0.98(0.75–1.27) 0.52
Infection (%)
 Pneumonia 52(41.0) 25(30.1) 27(61.4) 1.60(1.18–2.18) 0.0006
 UTI 51(40.2) 39(47.0) 12(27.3) 0.75(0.59–0.96) 0.02
 Bloodstream 9(7.0) 7(8.4) 2(4.5) 0.82(0.56–1.20) 0.33
 Tissue 13(10.2) 10(12.0) 3(6.8) 0.83(0.59–1.15) 0.27
 Abdominal 2(1.6) 2(2.4) 0 0.64(0.56–0.73) 0.42
 Sepsis 28(22.0) 27(32.5) 1(2.3) 0.58(0.48–0.70) 0.0001
 Severe sepsis 21(16.5) 17(20.5) 4(9.0) 0.76(0.59–0.99) 0.07
 Shock 63(49.6) 25(30.1) 38(86.4) 2.28(1.66–3.12) 0.0001
Infection site (%)
 Lungs 46(36.2) 23(27.7) 23(52.7) 1.48(1.07–2.03) 0.005
 Urine 51(40.2) 39(47.0) 12(27.3) 0.75(0.59–0.96) 0.02
 Blood 21(16.5) 11(13.2) 10(22.7) 1.29(0.84–1.99) 0.13
 Tissue 11 (8.7) 7(8.4) 4(9.1) 1.02(0.64–1.64) 0.56
 Others 8(8.0) 8(9.6) 0 0.63(0.54–0.72) 0.02
Pathogen (%)
K. pneumoniae 113(89.0) 74(89.2) 39(88.6) 0.98(0.64–1.48) 0.57
 Polymyxin-resistant 27(21.3) 17(20.5) 10(22.7) 1.04(0.75–1.44) 0.46
 Polymicrobial 55(43.3) 34(41.0) 21(47.7) 1.10(0.84–1.42) 0.29
 Co-infection A. baumannii 36(28.3) 22(26.5) 14(31.8) 1.09(0.81–1.47) 0.33
 Co-infection P. aeruginosa 13(10.2) 7(8.4) 6 (13.6) 1.23(0.73–2.08) 0.26
 blaKPC+ 96(75.6) 68(81.9) 28(63.6) 0.68(0.46–1.00) 0.02
  1. CRE carbapenem-resistant Enterobacteriaceae, RR relative risk, CI confidence interval, SD Standard deviation, LOS length of stay, IQR interquartile range, UTI urinary tract infection