Genotyping assay performance | Time | Designated composite prevalence (SD) | LA only | Sequential testing | ||
---|---|---|---|---|---|---|
Composite prevalence estimate (SD) | Estimate-to-true ratio | Composite prevalence estimate (SD) | Estimate-to-true ratio | |||
United States | ||||||
Sen = 1.00 Spe = 1.00 | Baseline | 0.019 (0.002) | 0.019 (0.002) | 1.000 | 0.003 (0.001) | 0.158 |
Reduced | 0.009 (0.002) | 0.009 (0.002) | 1.000 | 0.002 (0.001) | 0.222 | |
% Reduction | 52 | 52 | 33 | |||
Sen = 0.95 Spe = 0.95 | Baseline | 0.019 (0.002) | 0.067 (0.004) | 3.526 | 0.020 (0.002) | 1.053 |
Reduced | 0.009 (0.002) | 0.058 (0.004) | 6.444 | 0.017 (0.002) | 1.889 | |
% Reduction | 52 | 13.4 | 15 | |||
Sen = 0.95 Spe = 0.90 | Baseline | 0.019 (0.002) | 0.116 (0.005) | 6.105 | 0.043 (0.003) | 2.263 |
Reduced | 0.009 (0.002) | 0.108 (0.005) | 12.000 | 0.040 (0.003) | 4.444 | |
% Reduction | 52 | 6.9 | 7 | |||
Sen = 0.90 Spe = 0.90 | Baseline | 0.019 (0.002) | 0.115 (0.005) | 6.052 | 0.042 (0.003) | 2.210 |
Reduced | 0.009 (0.002) | 0.107 (0.005) | 11.889 | 0.039 (0.003) | 4.333 | |
% Reduction | 52 | 7.0 | 7.1 | |||
Sen = 0.90 Spe = 0.85 | Baseline | 0.019 (0.002) | 0.164 (0.006) | 8.632 | 0.066 (0.004) | 3.474 |
Reduced | 0.009 (0.002) | 0.157 (0.006) | 17.444 | 0.064 (0.004) | 7.111 | |
% Reduction | 52 | 4.3 | 3.0 | |||
Sen = 0.85 Spe = 0.85 | Baseline | 0.019 (0.002) | 0.163 (0.006) | 8.579 | 0.066 (0.004) | 3.474 |
Reduced | 0.009 (0.002) | 0.156 (0.006) | 17.33 | 0.063 (0.004) | 7.000 | |
% Reduction | 52 | 4.3 | 4.5 | |||
Sen = 0.80 Spe = 0.80 | Baseline | 0.019 (0.002) | 0.211 (0.006) | 11.105 | 0.090 (0.004) | 4.737 |
Reduced | 0.009 (0.002) | 0.206 (0.006) | 22.889 | 0.088 (0.005) | 9.778 | |
% Reduction | 52 | 2.3 | 2.2 | |||
Latin America | ||||||
Sen = 1.00 Spe = 1.00 | Baseline | 0.012 (0.002) | 0.012 (0.002) | 1.000 | 0.003 (0.001) | 0.250 |
Reduced | 0.006 (0.002) | 0.006 (0.002) | 1.000 | 0.001 (0.001) | 0.167 | |
% Reduction | 50 | 50 | 50 | |||
Sen = 0.95 Spe = 0.95 | Baseline | 0.012 (0.002) | 0.061 (0.004) | 5.083 | 0.016 (0.002) | 1.333 |
Reduced | 0.006 (0.002) | 0.056 (0.004) | 9.333 | 0.015 (0.002) | 2.500 | |
% Reduction | 50 | 8.2 | 6.3 | |||
Sen = 0.95 Spe = 0.90 | Baseline | 0.012 (0.002) | 0.110 (0.005) | 9.167 | 0.039 (0.003) | 3.250 |
Reduced | 0.006 (0.001) | 0.105 (0.005) | 17.500 | 0.037 (0.003) | 6.167 | |
% Reduction | 50 | 4.5 | 5.1 | |||
Sen = 0.90 Spe = 0.90 | Baseline | 0.012 (0.002) | 0.109 (0.005) | 9.083 | 0.039 (0.003) | 3.250 |
Reduced | 0.006 (0.001) | 0.105 (0.005) | 17.500 | 0.037 (0.003) | 6.167 | |
% Reduction | 50 | 3.7 | 5.1 | |||
Sen = 0.90 Spe = 0.85 | Baseline | 0.012 (0.002) | 0.159 (0.006) | 13.250 | 0.063 (0.004) | 5.250 |
Reduced | 0.006 (0.001) | 0.154 (0.006) | 25.667 | 0.062 (0.004) | 10.333 | |
% Reduction | 50 | 3.1 | 1.6 | |||
Sen = 0.85 Spe = 0.85 | Baseline | 0.012 (0.002) | 0.158 (0.006) | 13.167 | 0.063 (0.004) | 5.250 |
Reduced | 0.006 (0.001) | 0.154 (0.005) | 25.667 | 0.061 (0.004) | 10.166 | |
% Reduction | 50 | 3.1 | 3.1 | |||
Sen = 0.80 Spe = 0.80 | Baseline | 0.012 (0.002) | 0.207 (0.006) | 17.250 | 0.087 (0.004) | 7.250 |
Reduced | 0.006 (0.001) | 0.204 (0.006) | 34.000 | 0.086 (0.004) | 14.333 | |
% Reduction | 50 | 1.1 | 1.1 |